DegronMD

Uniprot ID: Q68CZ2

Source protein: Tensin-3

Source gene: TNS3

Class: DEG_ODPH_VHL_1

Location: 1011:1022

E3 ligase: VHL

DEGRON score: 0.6074

ASA_SCORE: 72.525

COIL: 0.8315

CONS_SCORE: 0.3465

DSS_SCORE: 0.5125

HELIX: 0.0932

FCONS_SCORE: 0.9826

RIG_SCORE: 0.6427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1025S	TCGA-05-4382	LUAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.25
p.A1025S	DO24900	LUAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.25
p.A1025T	TCGA-AA-3510	COAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.25
p.A1025T	DO7783	COAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.25
p.G1021S	TCGA-BR-A4J4	STAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.5882
p.G1021S	TCGA-D3-A8GI	SKCM	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.5882
p.G1021S	DO50284	SKCM	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.5882
p.G1021S	DO38671	STAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.5882
p.S1003F	TCGA-D3-A2JN	SKCM	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.1111
p.S1003F	DO47590	SKCM	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.1111
p.G1023S	TCGA-DM-A1D9	COAD	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.3056
p.G1023S	DO8866	COAD	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.3056
p.Q1017H	TCGA-ER-A19P	SKCM	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.647
p.Q1017H	DO47623	SKCM	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.647
p.L1011V	TCGA-P4-AAVM	KIRP	TCGA	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.6765
p.L1011V	DO219695	KIRP	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.6765
p.L1004Q	DO44740	LICA	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.1389
p.F1019L	DO220858	MELA	ICGC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.587
p.D1009E	SIDM00427	Ewing's Sarcoma	GDSC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.2778
p.D1009E	ACH-000499	Bone Cancer	CCLE	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.2778
p.D1009E	ACH-002194	Bone Cancer	CCLE	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.2778
p.D1009E	RH-1	soft_tissue	COSMIC	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.2778
p.L1031H	ACH-001959	Bile Duct Cancer	CCLE	LAPPSSQAFLGF	DEG_ODPH_VHL_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CZ2	Tensin-3	DEG_ODPH_VHL_1	1011:1022	LAPPSSQAFLGF	VHL	0.6074	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons