DegronMD

Uniprot ID: Q68CZ2

Source protein: Tensin-3

Source gene: TNS3

Class: DEG_SCF_FBW7_1

Location: 1212:1218

E3 ligase: FBXW7

DEGRON score: 0.5194

ASA_SCORE: 51.8857

COIL: 0.744

CONS_SCORE: 0.4758

DSS_SCORE: 0.2874

HELIX: 0.115

FCONS_SCORE: 1.0643

RIG_SCORE: 0.7457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1221L	TCGA-17-Z031	LUAD	TCGA	VATPPPS	DEG_SCF_FBW7_1	0.25
p.A1213V	TCGA-69-7979	LUAD	TCGA	VATPPPS	DEG_SCF_FBW7_1	0.5825
p.A1213V	DO23874	LUAD	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.5825
p.M1210I	TCGA-B5-A0JY	UCEC	TCGA	VATPPPS	DEG_SCF_FBW7_1	0.2778
p.M1210I	DO43041	UCEC	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.2778
p.D1228G	TCGA-BA-6869	HNSC	TCGA	VATPPPS	DEG_SCF_FBW7_1	0.0556
p.D1228G	DO14250	HNSC	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.0556
p.V1212G	TCGA-D3-A8GI	SKCM	TCGA	VATPPPS	DEG_SCF_FBW7_1	0.7532
p.V1212G	DO50284	SKCM	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.7532
p.G1227E	TCGA-IB-7651	PAAD	TCGA	VATPPPS	DEG_SCF_FBW7_1	0.0833
p.G1227E	DO46657	PAAD	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.0833
p.A1205S	DO234457	ESAD	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.1389
p.Q1221K	DO229018	LICA	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.25
p.N1223K	DO229026	LICA	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.1944
p.K1224E	DO229264	THCA	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.6111
p.P1216L	DO229221	THCA	ICGC	VATPPPS	DEG_SCF_FBW7_1	0.6471
p.S1218L	SIDM00399	Head and Neck Carcinoma	GDSC	VATPPPS	DEG_SCF_FBW7_1	0.8778
p.S1218L	ACH-001228		CCLE	VATPPPS	DEG_SCF_FBW7_1	0.8778
p.S1218L	SCC90	upper_aerodigestive_tract	COSMIC	VATPPPS	DEG_SCF_FBW7_1	0.8778

DegronMD: protein-targeted degradation, mutation and drug response to degrons