DegronMD

Uniprot ID: Q68CZ2

Source protein: Tensin-3

Source gene: TNS3

Class: DEG_SCF_TRCP1_1

Location: 392:397

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 78.7333

COIL: 0.8663

CONS_SCORE: 0.4348

DSS_SCORE: 0.6895

HELIX: 0.0915

FCONS_SCORE: 1.0736

RIG_SCORE: 0.5219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T402M	TCGA-AJ-A8CW	UCEC	TCGA	DSGHST	DEG_SCF_TRCP1_1	0.1944
p.T402M	DO48971	PBCA	ICGC	DSGHST	DEG_SCF_TRCP1_1	0.1944
p.T402M	DO52400	UCEC	ICGC	DSGHST	DEG_SCF_TRCP1_1	0.1944
p.V389I	TCGA-AZ-6601	COAD	TCGA	DSGHST	DEG_SCF_TRCP1_1	0.25
p.V389I	DO8119	COAD	ICGC	DSGHST	DEG_SCF_TRCP1_1	0.25
p.T386A	SIDM00933	Breast Carcinoma	GDSC	DSGHST	DEG_SCF_TRCP1_1	0.1667
p.T386A	ACH-000856	Breast Cancer	CCLE	DSGHST	DEG_SCF_TRCP1_1	0.1667
p.T386A	CAL-51	breast	COSMIC	DSGHST	DEG_SCF_TRCP1_1	0.1667
p.D384E	SIDM01752	Pancreatic Carcinoma	GDSC	DSGHST	DEG_SCF_TRCP1_1	0.1111
p.D384E	ACH-000685	Pancreatic Cancer	CCLE	DSGHST	DEG_SCF_TRCP1_1	0.1111
p.V389A	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGHST	DEG_SCF_TRCP1_1	0.25
p.V389A	SNU-1040	large_intestine	COSMIC	DSGHST	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68CZ2	Tensin-3	DEG_SCF_TRCP1_1	392:397	DSGHST	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons