DegronMD

Uniprot ID: Q63HR2

Source protein: Tensin-2

Source gene: TNS2

Class: DEG_SCF_FBW7_1

Location: 1031:1037

E3 ligase: FBXW7

DEGRON score: 0.9878

ASA_SCORE: 73.6

COIL: 0.9274

CONS_SCORE: 0.4095

DSS_SCORE: 0.6855

HELIX: 0.032

FCONS_SCORE: 1.0463

RIG_SCORE: 0.5997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1032A	SIDM01314	Colorectal Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	0.754
p.R1023C	SIDM00296	Small Cell Lung Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	0.1111
p.G1039W	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	PLTPVPS	DEG_SCF_FBW7_1	0.2778
p.G1039W	ABC-1	lung	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	0.2778
p.P1035S	HCT-15	large_intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	0.6752
p.K1034T	HCC2998	large_intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	0.7306
p.M1039I	SW48	large_intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	0.2778
p.R1023H	CW-2	large_intestine	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	0.1111
p.G1029W	ABC-1	lung	COSMIC	PLTPVPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SCF_FBW7_1	753:759	PLTPVPS	FBXW7	0.9718	More...
Q63HR2	Tensin-2	DEG_SCF_FBW7_1	1031:1037	PLTPVPS	FBXW7	0.9878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons