DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4232:4236

E3 ligase: SPOP

DEGRON score: 0.6101

ASA_SCORE: 77.86

COIL: 0.8678

CONS_SCORE: 0.3221

DSS_SCORE: 0.3157

HELIX: 0.0212

FCONS_SCORE: 0.9613

RIG_SCORE: 0.7072

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4232H	DO228835	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	0.7694
p.P4232L	TCGA-QC-A6FX	SARC	TCGA	PATSS	DEG_SPOP_SBC_1	0.7582
p.P4235L	DO220237	SARC	ICGC	PATSS	DEG_SPOP_SBC_1	0.7582
p.S4235R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	0.7427
p.S4235R	ACH-001127	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	0.7427
p.S4235R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	0.7427
p.A4236T	DO219773	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	0.7139
p.T4234A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	0.7139
p.T4234A	ACH-002238	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	0.7139
p.T4234A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	0.7139
p.S4236Y	SIDM00282	Colorectal Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.712
p.S4236Y	ACH-000998	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.712
p.S4236Y	CW-2	large_intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	0.712
p.A4233T	TCGA-EO-A3B0	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	0.6028
p.T4237K	SIDM00652	Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	0.3056
p.T4237K	ACH-000780	Lung Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	0.3056
p.T4237K	NCI-H1105	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	0.3056
p.T4237M	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PATSS	DEG_SPOP_SBC_1	0.3056
p.T4237M	ACH-001738	Leukemia	CCLE	PATSS	DEG_SPOP_SBC_1	0.3056
p.T4237M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PATSS	DEG_SPOP_SBC_1	0.3056
p.M4239T	TCGA-F4-6856	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	0.25
p.M4239T	22RV1	prostate	COSMIC	PATSS	DEG_SPOP_SBC_1	0.25
p.M4239T	SNU-175	large_intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	0.25
p.G4226S	TCGA-GS-A9TZ	DLBC	TCGA	PATSS	DEG_SPOP_SBC_1	0.1667
p.R4222S	DO14258	HNSC	ICGC	PATSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 25 entries

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Drug responses associated with MUC5B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PATSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCE9	Anoctamin-8	DEG_SPOP_SBC_1	939:943	PATSS	SPOP	0.7199	More...
Q9HBZ2	Aryl hydrocarbon receptor nuclear translocator 2	DEG_SPOP_SBC_1	619:623	PATSS	SPOP	0.9524	More...
P54252	Ataxin-3	DEG_SPOP_SBC_1	319:323	PATSS	SPOP	0.9966	More...
Q14687	Genetic suppressor element 1	DEG_SPOP_SBC_1	44:48	PATSS	SPOP	0.9439	More...
Q5SSJ5	Heterochromatin protein 1-binding protein 3	DEG_SPOP_SBC_1	87:91	PATSS	SPOP	0.9842	More...
Q9UPP1	Histone lysine demethylase PHF8	DEG_SPOP_SBC_1	774:778	PATSS	SPOP	0.9112	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	637:641	PATSS	SPOP	0.7297	More...
Q03112	Histone-lysine N-methyltransferase MECOM	DEG_SPOP_SBC_1	49:53	PATSS	SPOP	0.9868	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	187:191	PATSS	SPOP	0.8903	More...
Q96CB8	Integrator complex subunit 12	DEG_SPOP_SBC_1	321:325	PATSS	SPOP	0.8945	More...
Q9UKP3	Integrin beta-1-binding protein 2	DEG_SPOP_SBC_1	78:82	PATSS	SPOP	0.9254	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1004:1008	PATSS	SPOP	0.9683	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1889:1893	PATSS	SPOP	0.9045	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4232:4236	PATSS	SPOP	0.6101	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	930:934	PATSS	SPOP	0.9895	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	907:911	PATSS	SPOP	0.9948	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	892:896	PATSS	SPOP	0.9948	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	232:236	PATSS	SPOP	0.8979	More...
A6NGG8	Photoreceptor cilium actin regulator	DEG_SPOP_SBC_1	1125:1129	PATSS	SPOP	0.9621	More...
P35227	Polycomb group RING finger protein 2	DEG_SPOP_SBC_1	270:274	PATSS	SPOP	0.9677	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	152:156	PATSS	SPOP	0.7702	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	514:518	PATSS	SPOP	0.985	More...
Q3SYA9	Putative POM121-like protein 1	DEG_SPOP_SBC_1	333:337	PATSS	SPOP	0.9106	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	563:567	PATSS	SPOP	0.9988	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	835:839	PATSS	SPOP	0.9635	More...

Showing 1 to 25 of 35 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATSS

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of PATSS