DegronMD

Uniprot ID: P35227

Source protein: Polycomb group RING finger protein 2

Source gene: PCGF2

Class: DEG_SCF_FBW7_1

Location: 321:327

E3 ligase: FBXW7

DEGRON score: 0.7769

ASA_SCORE: 90.5714

COIL: 0.906

CONS_SCORE: 0.381

DSS_SCORE: 0.6482

HELIX: 0.0633

FCONS_SCORE: 1.0145

RIG_SCORE: 0.6747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K332N	TCGA-AJ-A3EL	UCEC	TCGA	LQTPSST	DEG_SCF_FBW7_1	0.3056
p.K332N	DO233749	GACA	ICGC	LQTPSST	DEG_SCF_FBW7_1	0.3056
p.K332N	DO41542	UCEC	ICGC	LQTPSST	DEG_SCF_FBW7_1	0.3056
p.P324Q	SIDM00193	Colorectal Carcinoma	GDSC	LQTPSST	DEG_SCF_FBW7_1	0.7035
p.P324Q	ACH-000991	Colon/Colorectal Cancer	CCLE	LQTPSST	DEG_SCF_FBW7_1	0.7035
p.A313V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LQTPSST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35227	Polycomb group RING finger protein 2	DEG_SCF_FBW7_1	321:327	LQTPSST	FBXW7	0.7769	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons