DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KRLTLATVP
Uniprot ID:
P35227
Source protein:
Polycomb group RING finger protein 2
Source gene:
PCGF2
Class:
DEG_APCC_DBOX_1
Location:
234:242
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6072
ASA_SCORE:
106.1333
COIL:
0.8562
CONS_SCORE:
0.4131
DSS_SCORE:
0.4146
HELIX:
0.0487
FCONS_SCORE:
0.9402
RIG_SCORE:
0.7785
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A239V
DO231722
LINC
ICGC
KRLTLATVP
DEG_APCC_DBOX_1
0.5825
p.P244L
DO230522
LUSC
ICGC
KRLTLATVP
DEG_APCC_DBOX_1
0.2778
Drug responses associated with PCGF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KRLTLATVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35227
Polycomb group RING finger protein 2
DEG_APCC_DBOX_1
234:242
KRLTLATVP
APC,CDC20,FZR1
0.6072
More...