DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_SCF_FBW7_1

Location: 494:500

E3 ligase: FBXW7

DEGRON score: 0.9682

ASA_SCORE: 92.6571

COIL: 0.9761

CONS_SCORE: 0.3529

DSS_SCORE: 0.8845

HELIX: 0.0097

FCONS_SCORE: 0.8632

RIG_SCORE: 0.493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P495S	DO222638	MELA	ICGC	PPTPTPS	DEG_SCF_FBW7_1	0.5641
p.G491S	SIDM00855	Other Sarcomas	GDSC	PPTPTPS	DEG_SCF_FBW7_1	0.25
p.G491S	SIDM00785	Acute Myeloid Leukemia	GDSC	PPTPTPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SCF_FBW7_1	494:500	PPTPTPS	FBXW7	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons