DegronMD

Uniprot ID: Q9UMN6

Source protein: Histone-lysine N-methyltransferase 2B

Source gene: KMT2B

Class: DEG_APCC_DBOX_1

Location: 2354:2362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9807

ASA_SCORE: 95.4111

COIL: 0.9454

CONS_SCORE: 0.3574

DSS_SCORE: 0.8439

HELIX: 0.0273

FCONS_SCORE: 1.112

RIG_SCORE: 0.6036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2368H	TCGA-37-3792	LUSC	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	0.1667
p.Q2368H	DO233267	GACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.1667
p.Q2368H	DO27192	LUSC	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.1667
p.G2372V	TCGA-AN-A0AK	BRCA	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	0.0556
p.G2372V	DO1608	BRCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.0556
p.G2372V	DO229245	THCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.0556
p.P2370S	TCGA-FW-A3R5	SKCM	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	0.1111
p.P2370S	DO37406	SKCM	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.1111
p.S2356F	TCGA-Z2-A8RT	SKCM	TCGA	ERSPLLPLP	DEG_APCC_DBOX_1	0.6871
p.S2356F	DO222402	MELA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.6871
p.S2356F	DO51301	SKCM	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.6871
p.D2364G	DO229010	COCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.2778
p.D2364G	DO229016	COCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.2778
p.D2364G	DO229005	COCA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.2778
p.D2364G	DO231204	LUSC	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.2778
p.P2370L	DO233693	GACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.1111
p.D2371N	DO229346	LAML	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.0833
p.P2367H	DO232832	NACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.1944
p.P2360Q	DO233296	NACA	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.5924
p.S2356A	DO46483	OV	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.6477
p.E2346Q	DO29760	OV	ICGC	ERSPLLPLP	DEG_APCC_DBOX_1	0.1111
p.R2355W	SIDM00846	Cervical Carcinoma	GDSC	ERSPLLPLP	DEG_APCC_DBOX_1	0.8634
p.E2354K	SIDM00735	Small Cell Lung Carcinoma	GDSC	ERSPLLPLP	DEG_APCC_DBOX_1	0.591
p.E2354K	NCI-H2029	lung	COSMIC	ERSPLLPLP	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_APCC_DBOX_1	2354:2362	ERSPLLPLP	APC,CDC20,FZR1	0.9807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons