DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: DEG_APCC_DBOX_1

Location: 359:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9741

ASA_SCORE: 106.3222

COIL: 0.9366

CONS_SCORE: 0.7132

DSS_SCORE: 0.7786

HELIX: 0.041

FCONS_SCORE: 1.1243

RIG_SCORE: 0.6337

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L363F	TCGA-69-7765	LUAD	TCGA	ARPSLATVQ	DEG_APCC_DBOX_1	0.6981
p.L363F	DO23580	LUAD	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	0.6981
p.G351S	TCGA-A6-6781	COAD	TCGA	ARPSLATVQ	DEG_APCC_DBOX_1	0.1111
p.G351S	TCGA-D5-6530	COAD	TCGA	ARPSLATVQ	DEG_APCC_DBOX_1	0.1111
p.G351S	DO8447	COAD	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	0.1111
p.G351S	DO8312	COAD	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	0.1111
p.M353I	DO230342	COCA	ICGC	ARPSLATVQ	DEG_APCC_DBOX_1	0.1667
p.P377S	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ARPSLATVQ	DEG_APCC_DBOX_1	0.0556
p.P377S	ACH-000636	Leukemia	CCLE	ARPSLATVQ	DEG_APCC_DBOX_1	0.0556
p.P377S	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	ARPSLATVQ	DEG_APCC_DBOX_1	0.0556
p.P350S	SIDM01653	Non-Cancerous	GDSC	ARPSLATVQ	DEG_APCC_DBOX_1	0.0833
p.P350S	ACH-002351	Non-Cancerous	CCLE	ARPSLATVQ	DEG_APCC_DBOX_1	0.0833
p.H371Q	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	ARPSLATVQ	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14686	Nuclear receptor coactivator 6	DEG_APCC_DBOX_1	359:367	ARPSLATVQ	APC,CDC20,FZR1	0.9741	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons