DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: DEG_ODPH_VHL_1

Location: 236:248

E3 ligase: VHL

DEGRON score: 0.8755

ASA_SCORE: 105.0154

COIL: 0.9585

CONS_SCORE: 0.5791

DSS_SCORE: 0.838

HELIX: 0.0252

FCONS_SCORE: 0.9279

RIG_SCORE: 0.548

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P242S	TCGA-85-A50Z	LUSC	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.5641
p.P242S	DO45462	LUSC	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.5641
p.S235Y	TCGA-A5-A0G1	UCEC	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.3056
p.S235Y	DO42472	UCEC	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.3056
p.N249S	TCGA-CK-4951	COAD	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.3056
p.N249S	DO10582	COAD	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.3056
p.P258L	TCGA-D3-A5GO	SKCM	TCGA	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.0556
p.P258L	DO47419	SKCM	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.0556
p.H231N	DO229045	LICA	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.1944
p.P239R	DO231075	LUSC	ICGC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01151	Hepatocellular Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00607	Glioblastoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00596	Endometrial Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00245	Small Cell Lung Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01210	Glioblastoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00368	Small Cell Lung Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00566	Oral Cavity Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00560	Gastric Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01444	Glioblastoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01776	Plasma Cell Myeloma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01472	Hepatocellular Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01464	Pancreatic Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01469	Pancreatic Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM00161	Biliary Tract Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01448	Head and Neck Carcinoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.P239R	SIDM01559	Melanoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6401
p.S247P	SIDM00845	Burkitt's Lymphoma	GDSC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.5641
p.M243V	ACH-001617	Lymphoma	CCLE	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6097
p.M243V	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPHHPMQPVSV	DEG_ODPH_VHL_1	0.6097

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPHHPMQPVSV

Degron related mutations and impact score

Drug responses associated with NCOA6 mutations

All proteins holding degron of LAPPHHPMQPVSV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14686	Nuclear receptor coactivator 6	DEG_ODPH_VHL_1	236:248	LAPPHHPMQPVSV	VHL	0.8755	More...