DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: LIG_APCC_ABBAyCdc20_2

Location: 1110:1116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9889

ASA_SCORE: 130.2429

COIL: 0.9429

CONS_SCORE: 0.61

DSS_SCORE: 0.7159

HELIX: 0.0319

FCONS_SCORE: 1.0764

RIG_SCORE: 0.6635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1119H	TCGA-AG-A002	READ	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.25
p.S1124L	TCGA-AJ-A3BD	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S1124L	DO40813	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P1118L	TCGA-AJ-A3EK	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1118L	TCGA-BS-A0UF	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1118L	TCGA-FP-A4BE	STAD	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1118L	DO48016	STAD	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1118L	DO41584	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1118L	DO41488	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P1125S	TCGA-FI-A2D5	UCEC	TCGA	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P1125S	DO41331	UCEC	ICGC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.S1123T	SIDM00848	Ewing's Sarcoma	GDSC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1112R	ACH-000991	Colon/Colorectal Cancer	CCLE	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.7521
p.M1112R	SNU-81	large_intestine	COSMIC	RKMVYQE	LIG_APCC_ABBAyCdc20_2	0.7521

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14686	Nuclear receptor coactivator 6	LIG_APCC_ABBAyCdc20_2	1110:1116	RKMVYQE	APC,CDC20,FZR1	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons