DegronMD

Uniprot ID: Q14686

Source protein: Nuclear receptor coactivator 6

Source gene: NCOA6

Class: DEG_SCF_FBW7_1

Location: 1100:1107

E3 ligase: FBXW7

DEGRON score: 0.9868

ASA_SCORE: 94.7625

COIL: 0.971

CONS_SCORE: 0.5563

DSS_SCORE: 0.6928

HELIX: 0.0138

FCONS_SCORE: 1.0292

RIG_SCORE: 0.6186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1098S	TCGA-AA-3510	COAD	TCGA	PVNTPLGS	DEG_SCF_FBW7_1	0.2778
p.P1098S	DO7783	COAD	ICGC	PVNTPLGS	DEG_SCF_FBW7_1	0.2778
p.S1107N	SIDM00525	Osteosarcoma	GDSC	PVNTPLGS	DEG_SCF_FBW7_1	0.7069
p.S1107N	ACH-000359	Bone Cancer	CCLE	PVNTPLGS	DEG_SCF_FBW7_1	0.7069
p.S1107N	MG-63	bone	COSMIC	PVNTPLGS	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14686	Nuclear receptor coactivator 6	DEG_SCF_FBW7_1	1100:1107	PVNTPLGS	FBXW7	0.9868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons