DegronMD

Uniprot ID: Q86TB3

Source protein: Alpha-protein kinase 2

Source gene: ALPK2

Class: LIG_APCC_ABBA_1

Location: 433:438

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6201

ASA_SCORE: 87.9667

COIL: 0.8978

CONS_SCORE: 0.414

DSS_SCORE: 0.703

HELIX: 0.0345

FCONS_SCORE: 1.237

RIG_SCORE: 0.6459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L433F	TCGA-05-4396	LUAD	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.587
p.L433F	DO23838	LUAD	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.587
p.Q437K	TCGA-77-7463	LUSC	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.5833
p.Q437K	DO26716	LUSC	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.5833
p.H436Q	TCGA-77-7463	LUSC	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.7582
p.H436Q	DO26716	LUSC	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.7582
p.R448I	TCGA-A5-A0G1	UCEC	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.0556
p.R448I	DO42472	UCEC	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.0556
p.L431H	TCGA-AB-2806	LAML	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.2778
p.L431H	DO21283	LAML	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.2778
p.Q437P	TCGA-BS-A0UJ	UCEC	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.5924
p.Q437P	DO42745	UCEC	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.5924
p.G439R	TCGA-EE-A2A5	SKCM	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.3056
p.G439R	DO37941	SKCM	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.3056
p.P435H	TCGA-GN-A263	SKCM	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.7694
p.P435H	DO37766	SKCM	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.7694
p.E445K	TCGA-IA-A83W	KIRP	TCGA	LGPHQD	LIG_APCC_ABBA_1	0.1389
p.E445K	DO51566	KIRP	ICGC	LGPHQD	LIG_APCC_ABBA_1	0.1389
p.G434E	SIDM00217	Colorectal Carcinoma	GDSC	LGPHQD	LIG_APCC_ABBA_1	0.6087
p.G434E	ACH-000999	Colon/Colorectal Cancer	CCLE	LGPHQD	LIG_APCC_ABBA_1	0.6087
p.G434E	SNU-1040	large_intestine	COSMIC	LGPHQD	LIG_APCC_ABBA_1	0.6087
p.T427S	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LGPHQD	LIG_APCC_ABBA_1	0.1667
p.T427S	ACH-000912	Lung Cancer	CCLE	LGPHQD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TB3	Alpha-protein kinase 2	LIG_APCC_ABBA_1	433:438	LGPHQD	APC,CDC20,FZR1	0.6201	More...
Q9H8Y5	Ankyrin repeat and zinc finger domain-containing protein 1	LIG_APCC_ABBA_1	182:187	LGPHQD	APC,CDC20,FZR1	0.9188	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons