DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGPHQD
Uniprot ID:
Q9H8Y5
Source protein:
Ankyrin repeat and zinc finger domain-containing protein 1
Source gene:
ANKZF1
Class:
LIG_APCC_ABBA_1
Location:
182:187
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9188
ASA_SCORE:
62.6833
COIL:
0.8893
CONS_SCORE:
0.2675
DSS_SCORE:
0.2563
HELIX:
0.0487
FCONS_SCORE:
0.7664
RIG_SCORE:
0.7161
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L175F
DO222645
ESCA
ICGC
LGPHQD
LIG_APCC_ABBA_1
0.1389
p.H185R
DO231201
LUSC
ICGC
LGPHQD
LIG_APCC_ABBA_1
0.8244
Drug responses associated with ANKZF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGPHQD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86TB3
Alpha-protein kinase 2
LIG_APCC_ABBA_1
433:438
LGPHQD
APC,CDC20,FZR1
0.6201
More...
Q9H8Y5
Ankyrin repeat and zinc finger domain-containing protein 1
LIG_APCC_ABBA_1
182:187
LGPHQD
APC,CDC20,FZR1
0.9188
More...