DegronMD - Q9H8Y5(ANKZF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K310T	TCGA-38-4631	LUAD	TCGA	LQRGDPR	SCF_FBXL2	314:320	Mutation blocking ubiquitination signal	0.6667
p.K310T	DO24970	LUAD	ICGC	LQRGDPR	SCF_FBXL2	314:320	Mutation blocking ubiquitination signal	0.6667
p.G317V	TCGA-61-2003	OV	TCGA	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7532
p.G317V	DO31300	OV	ICGC	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7532
p.R617W	TCGA-AA-3672	COAD	TCGA	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.1667
p.R617W	DO9010	COAD	ICGC	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.1667
p.R617W	DO229162	NKTL	ICGC	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.1667
p.Q601R	TCGA-AJ-A8CV	UCEC	TCGA	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.2222
p.Q601R	DO219766	UCEC	ICGC	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.2222
p.M610L	TCGA-CA-6717	COAD	TCGA	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation altering degron motif	0.5999
p.M610L	DO8264	COAD	ICGC	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation altering degron motif	0.5999
p.G317R	TCGA-CQ-6222	HNSC	TCGA	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7568
p.G317R	DO14433	HNSC	ICGC	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7568
p.F306L	DO223002	ESCA	ICGC	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.1111
p.L175F	DO222645	ESCA	ICGC	LGPHQD	LIG_APCC_ABBA_1	182:187	Mutation rewiring degron network	0.1389
p.H185R	DO231201	LUSC	ICGC	LGPHQD	LIG_APCC_ABBA_1	182:187	Mutation altering degron motif	0.8244
p.R329C	SIDM01943	Colorectal Carcinoma	GDSC	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.0833
p.R613W	SIDM00180	Kidney Carcinoma	GDSC	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.2778
p.R613W	SIDM01645	Non-Cancerous	GDSC	PLTPEME	DEG_SCF_FBW7_2	605:611	Mutation rewiring degron network	0.2778
p.R320Q	SIDM01573	Plasma Cell Myeloma	GDSC	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7329
p.R320Q	ACH-000576	Myeloma	CCLE	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7329
p.A327T	SIDM00500	Colorectal Carcinoma	GDSC	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.1389
p.A327T	ACH-000959	Colon/Colorectal Cancer	CCLE	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.1389
p.G308E	ACH-001690	Head and Neck Cancer	CCLE	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.1667
p.D318N	ACH-002024	Colon/Colorectal Cancer	CCLE	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.5821
p.S307N	KP-3	pancreas	COSMIC	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.1389
p.P320L	MCC26	skin	COSMIC	LQRGDPR	SCF_FBXL2	314:320	Mutation altering degron motif	0.7582
p.S323F	LoVo	large intestine	COSMIC	LQRGDPR	SCF_FBXL2	314:320	Mutation rewiring degron network	0.25

Kaplan plot for ANKZF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKZF1

UniProt ID: Q9H8Y5

Entrez ID: 55139

Protein name: Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKZF1 in