DegronMD

Uniprot ID: Q9H8Y5

Source protein: Ankyrin repeat and zinc finger domain-containing protein 1

Source gene: ANKZF1

Class: SCF_FBXL2

Location: 314:320

E3 ligase: FBXL2

DEGRON score: 0.8921

ASA_SCORE: 62.9

COIL: 0.8116

CONS_SCORE: 0.4999

DSS_SCORE: 0.3551

HELIX: 0.0409

FCONS_SCORE: 1.0216

RIG_SCORE: 0.7082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K310T	TCGA-38-4631	LUAD	TCGA	LQRGDPR	SCF_FBXL2	0.6667
p.K310T	DO24970	LUAD	ICGC	LQRGDPR	SCF_FBXL2	0.6667
p.G317V	TCGA-61-2003	OV	TCGA	LQRGDPR	SCF_FBXL2	0.7532
p.G317V	DO31300	OV	ICGC	LQRGDPR	SCF_FBXL2	0.7532
p.G317R	TCGA-CQ-6222	HNSC	TCGA	LQRGDPR	SCF_FBXL2	0.7568
p.G317R	DO14433	HNSC	ICGC	LQRGDPR	SCF_FBXL2	0.7568
p.F306L	DO223002	ESCA	ICGC	LQRGDPR	SCF_FBXL2	0.1111
p.R329C	SIDM01943	Colorectal Carcinoma	GDSC	LQRGDPR	SCF_FBXL2	0.0833
p.R320Q	SIDM01573	Plasma Cell Myeloma	GDSC	LQRGDPR	SCF_FBXL2	0.7329
p.R320Q	ACH-000576	Myeloma	CCLE	LQRGDPR	SCF_FBXL2	0.7329
p.A327T	SIDM00500	Colorectal Carcinoma	GDSC	LQRGDPR	SCF_FBXL2	0.1389
p.A327T	ACH-000959	Colon/Colorectal Cancer	CCLE	LQRGDPR	SCF_FBXL2	0.1389
p.G308E	ACH-001690	Head and Neck Cancer	CCLE	LQRGDPR	SCF_FBXL2	0.1667
p.D318N	ACH-002024	Colon/Colorectal Cancer	CCLE	LQRGDPR	SCF_FBXL2	0.5821
p.S307N	KP-3	pancreas	COSMIC	LQRGDPR	SCF_FBXL2	0.1389
p.P320L	MCC26	skin	COSMIC	LQRGDPR	SCF_FBXL2	0.7582
p.S323F	LoVo	large_intestine	COSMIC	LQRGDPR	SCF_FBXL2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8Y5	Ankyrin repeat and zinc finger domain-containing protein 1	SCF_FBXL2	314:320	LQRGDPR	FBXL2	0.8921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons