DegronMD

Uniprot ID: Q9H8Y5

Source protein: Ankyrin repeat and zinc finger domain-containing protein 1

Source gene: ANKZF1

Class: DEG_SCF_FBW7_2

Location: 605:611

E3 ligase: FBXW7

DEGRON score: 0.6472

ASA_SCORE: 79.0143

COIL: 0.4803

CONS_SCORE: 0.4577

DSS_SCORE: 0.6864

HELIX: 0.5209

FCONS_SCORE: 1.0509

RIG_SCORE: 0.6624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R617W	TCGA-AA-3672	COAD	TCGA	PLTPEME	DEG_SCF_FBW7_2	0.1667
p.R617W	DO9010	COAD	ICGC	PLTPEME	DEG_SCF_FBW7_2	0.1667
p.R617W	DO229162	NKTL	ICGC	PLTPEME	DEG_SCF_FBW7_2	0.1667
p.Q601R	TCGA-AJ-A8CV	UCEC	TCGA	PLTPEME	DEG_SCF_FBW7_2	0.2222
p.Q601R	DO219766	UCEC	ICGC	PLTPEME	DEG_SCF_FBW7_2	0.2222
p.M610L	TCGA-CA-6717	COAD	TCGA	PLTPEME	DEG_SCF_FBW7_2	0.5999
p.M610L	DO8264	COAD	ICGC	PLTPEME	DEG_SCF_FBW7_2	0.5999
p.R613W	SIDM00180	Kidney Carcinoma	GDSC	PLTPEME	DEG_SCF_FBW7_2	0.2778
p.R613W	SIDM01645	Non-Cancerous	GDSC	PLTPEME	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8Y5	Ankyrin repeat and zinc finger domain-containing protein 1	DEG_SCF_FBW7_2	605:611	PLTPEME	FBXW7	0.6472	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons