DegronMD

Uniprot ID: Q9H254

Source protein: Spectrin beta chain, non-erythrocytic 4

Source gene: SPTBN4

Class: DEG_SPOP_SBC_1

Location: 2540:2544

E3 ligase: SPOP

DEGRON score: 0.9961

ASA_SCORE: 88.74

COIL: 0.9544

CONS_SCORE: 0.3751

DSS_SCORE: 0.6847

HELIX: 0.0252

FCONS_SCORE: 1.0668

RIG_SCORE: 0.6501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2552K	TCGA-55-6972	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R2552K	DO25010	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.A2533T	TCGA-77-8140	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1389
p.A2533T	DO26834	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1389
p.G2536D	TCGA-BF-AAOU	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2222
p.G2536D	DO219460	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.S2544C	TCGA-EL-A3ZO	THCA	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7541
p.S2544C	DO49869	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7541
p.R2534H	DO233210	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.A2530S	DO229026	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.A2530S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.A2530S	ACH-000837	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.0556
p.A2530S	NCI-H322M	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.Q2537H	DO50817	LIRI	ICGC	PTTSS	DEG_SPOP_SBC_1	0.25
p.W2535R	SIDM00846	Cervical Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.W2535R	ACH-001086	Cervical Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1944
p.W2535R	HeLa	cervix	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.K2551N	SIDM00006	Other Solid Cancers	GDSC	PTTSS	DEG_SPOP_SBC_1	0.25
p.K2551N	ACH-001552	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.25
p.K2551N	MCC26	skin	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with SPTBN4 mutations

All proteins holding degron of PTTSS