DegronMD

Uniprot ID: Q15915

Source protein: Zinc finger protein ZIC 1

Source gene: ZIC1

Class: DEG_SPOP_SBC_1

Location: 417:421

E3 ligase: SPOP

DEGRON score: 0.9909

ASA_SCORE: 89.06

COIL: 0.9458

CONS_SCORE: 0.4151

DSS_SCORE: 0.6157

HELIX: 0.0356

FCONS_SCORE: 1.1174

RIG_SCORE: 0.5857

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P417T	TCGA-25-1319	OV	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7031
p.P417T	DO233893	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7031
p.P417T	DO32526	OV	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7031
p.S411F	TCGA-BT-A20J	BLCA	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1667
p.S411F	DO457	BLCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.S426F	TCGA-D3-A8GI	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S426F	TCGA-EE-A2M6	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S426F	DO222514	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S426F	DO50284	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S426F	DO37976	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S425P	TCGA-G4-6309	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2222
p.S425P	DO7810	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.S425P	DO227906	COCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.T419K	TCGA-L3-A524	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7306
p.T419K	DO45476	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7306
p.P417L	TCGA-Z2-A8RT	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7582
p.P417L	DO51301	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7582
p.T414K	DO228131	EOPC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.25
p.D415E	DO233171	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.H430N	DO23164	LINC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.S423L	DO220881	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.S423L	DO224719	PACA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.S413F	DO222908	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.T408P	DO35571	PBCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0833
p.P407T	DO230449	UTCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.L422I	SIDM00698	Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.3056
p.L422I	ACH-000506	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.3056
p.L422I	NCI-H146	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.3056
p.S426T	SIDM00282	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S426T	ACH-000998	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S426T	CW-2	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.I409M	SIDM00861	Ovarian Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.I409M	ACH-000906	Ovarian Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1111
p.I409M	ES-2	ovary	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.P424L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.25
p.P424L	ACH-000925	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with ZIC1 mutations

All proteins holding degron of PTTSS