DegronMD - Q9H3M9(ATXN3L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S323G	TCGA-34-5240	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.S323G	DO26563	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.S326T	TCGA-37-3783	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5556
p.S326T	DO26734	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation blocking phosphorylation signal	0.5556
p.S323N	TCGA-A5-A1OF	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.S323N	DO42568	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.S318L	TCGA-AA-A00N	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	TCGA-AX-A05Z	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	TCGA-AX-A06F	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	TCGA-EO-A3B0	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	TCGA-F5-6814	READ	TCGA	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	DO9876	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	DO222702	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	DO36556	READ	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	DO219773	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	DO40884	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S318L	DO41752	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.E312K	DO222504	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.E312K	SIDM00681	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.E312K	ACH-000252	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.E312K	LS-1034	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.S308L	SIDM00631	Breast Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.S308L	ACH-001358	Breast Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.S308L	MDA-MB-330	breast	COSMIC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.L325F	SIDM00177	Melanoma	GDSC	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.L325F	ACH-002338	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.L325F	ACH-002510	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389

Kaplan plot for ATXN3L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATXN3L

UniProt ID: Q9H3M9

Entrez ID: 92552

Protein name: Ataxin-3-like protein (EC 3.4.19.12) (Machado-Joseph disease protein 1-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATXN3L in