DegronMD

Uniprot ID: Q9H3M9

Source protein: Ataxin-3-like protein

Source gene: ATXN3L

Class: DEG_SPOP_SBC_1

Location: 314:318

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 79.92

COIL: 0.9004

CONS_SCORE: 0.3486

DSS_SCORE: 0.6414

HELIX: 0.0736

FCONS_SCORE: 1.0811

RIG_SCORE: 0.6205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S323G	TCGA-34-5240	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S323G	DO26563	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S326T	TCGA-37-3783	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.5556
p.S326T	DO26734	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.5556
p.S323N	TCGA-A5-A1OF	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S323N	DO42568	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.S318L	TCGA-AA-A00N	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	TCGA-AX-A05Z	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	TCGA-AX-A06F	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	TCGA-EO-A3B0	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	TCGA-F5-6814	READ	TCGA	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	DO9876	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	DO222702	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	DO36556	READ	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	DO219773	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	DO40884	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7667
p.S318L	DO41752	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.7667
p.E312K	DO222504	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.E312K	SIDM00681	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.E312K	ACH-000252	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.2778
p.E312K	LS-1034	large_intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.S308L	SIDM00631	Breast Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.S308L	ACH-001358	Breast Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1667
p.S308L	MDA-MB-330	breast	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1667
p.L325F	SIDM00177	Melanoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1389
p.L325F	ACH-002338	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1389
p.L325F	ACH-002510	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with ATXN3L mutations

All proteins holding degron of PTTSS