DegronMD - Q9H254(SPTBN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2552K	TCGA-55-6972	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1111
p.R2552K	DO25010	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1111
p.A2533T	TCGA-77-8140	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1389
p.A2533T	DO26834	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1389
p.G2536D	TCGA-BF-AAOU	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.2222
p.G2536D	DO219460	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.2222
p.S2544C	TCGA-EL-A3ZO	THCA	TCGA	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation altering degron motif	0.7541
p.S2544C	DO49869	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation altering degron motif	0.7541
p.R2534H	DO233210	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1667
p.A2530S	DO229026	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.0556
p.A2530S	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.0556
p.A2530S	ACH-000837	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.0556
p.A2530S	NCI-H322M	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.0556
p.Q2537H	DO50817	LIRI	ICGC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.25
p.W2535R	SIDM00846	Cervical Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1944
p.W2535R	ACH-001086	Cervical Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1944
p.W2535R	HeLa	cervix	COSMIC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation rewiring degron network	0.1944
p.K2551N	SIDM00006	Other Solid Cancers	GDSC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation substituting flanking lysine	0.25
p.K2551N	ACH-001552	Skin Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation substituting flanking lysine	0.25
p.K2551N	MCC26	skin	COSMIC	PTTSS	DEG_SPOP_SBC_1	2540:2544	Mutation substituting flanking lysine	0.25

Kaplan plot for SPTBN4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTBN4

UniProt ID: Q9H254

Entrez ID: 57731

Protein name: Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTBN4 in