DegronMD

Uniprot ID: Q9Y5J3

Source protein: Hairy/enhancer-of-split related with YRPW motif protein 1

Source gene: HEY1

Class: DEG_SPOP_SBC_1

Location: 41:45

E3 ligase: SPOP

DEGRON score: 0.6104

ASA_SCORE: 89.62

COIL: 0.7372

CONS_SCORE: 0.4411

DSS_SCORE: 0.6121

HELIX: 0.2544

FCONS_SCORE: 0.84

RIG_SCORE: 0.6775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A49T	TCGA-BG-A222	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	0.2222
p.A49T	DO42977	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2222
p.S34L	TCGA-K4-A83P	BLCA	TCGA	PTTSS	DEG_SPOP_SBC_1	0.1389
p.S34L	DO49787	BLCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1389
p.L36V	DO225215	BRCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.L36V	DO227836	BRCA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.C40W	DO49778	KIRP	ICGC	PTTSS	DEG_SPOP_SBC_1	0.3056
p.I50S	DO228207	LICA	ICGC	PTTSS	DEG_SPOP_SBC_1	0.1944
p.D31G	DO50814	LIRI	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.D31E	DO228382	MALY	ICGC	PTTSS	DEG_SPOP_SBC_1	0.0556
p.I51T	DO29628	OV	ICGC	PTTSS	DEG_SPOP_SBC_1	0.2778
p.R53P	SIDM00600	Thyroid Gland Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R53P	ACH-001528	Thyroid Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1111
p.R53P	IHH-4	thyroid	COSMIC	PTTSS	DEG_SPOP_SBC_1	0.1111
p.G53V	ACH-000921	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1111
p.L36I	ACH-000966	Ovarian Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	261:265	PTTSS	SPOP	0.9948	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	549:553	PTTSS	SPOP	0.8155	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1250:1254	PTTSS	SPOP	0.9955	More...
P35869	Aryl hydrocarbon receptor	DEG_SPOP_SBC_1	730:734	PTTSS	SPOP	0.9973	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	4:8	PTTSS	SPOP	0.9972	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	2207:2211	PTTSS	SPOP	0.9961	More...
Q15915	Zinc finger protein ZIC 1	DEG_SPOP_SBC_1	417:421	PTTSS	SPOP	0.9909	More...
Q7Z7G0	Target of Nesh-SH3	DEG_SPOP_SBC_1	341:345	PTTSS	SPOP	0.992	More...
Q8IZF0	Sodium leak channel NALCN	DEG_SPOP_SBC_1	682:686	PTTSS	SPOP	0.8231	More...
Q8N0V3	Putative ribosome-binding factor A, mitochondrial	DEG_SPOP_SBC_1	230:234	PTTSS	SPOP	0.9938	More...
Q8N7W2	BEN domain-containing protein 7	DEG_SPOP_SBC_1	144:148	PTTSS	SPOP	0.6957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	6756:6760	PTTSS	SPOP	0.7898	More...
Q9BRK4	Leucine zipper putative tumor suppressor 2	DEG_SPOP_SBC_1	238:242	PTTSS	SPOP	0.9196	More...
Q9H1H9	Kinesin-like protein KIF13A	DEG_SPOP_SBC_1	1590:1594	PTTSS	SPOP	0.9958	More...
Q9H254	Spectrin beta chain, non-erythrocytic 4	DEG_SPOP_SBC_1	2540:2544	PTTSS	SPOP	0.9961	More...
Q9Y5J3	Hairy/enhancer-of-split related with YRPW motif protein 1	DEG_SPOP_SBC_1	41:45	PTTSS	SPOP	0.6104	More...
Q9H3M9	Ataxin-3-like protein	DEG_SPOP_SBC_1	314:318	PTTSS	SPOP	0.999	More...
O75333	T-box transcription factor TBX10	DEG_SPOP_SBC_1	21:25	PTTSS	SPOP	0.988	More...
Q5JXX7	Transmembrane protein 31	DEG_SPOP_SBC_1	60:64	PTTSS	SPOP	0.5118	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTSS

Degron related mutations and impact score

Drug responses associated with HEY1 mutations

All proteins holding degron of PTTSS