DegronMD - Q7Z7G0(ABI3BP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S499R	TCGA-13-1497	OV	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.0833
p.R104L	TCGA-55-8203	LUAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.0556
p.R104L	DO218928	LUAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.0556
p.R120L	TCGA-86-8358	LUAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.8428
p.R120L	DO25471	LUAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.8428
p.P494T	TCGA-91-A4BC	LUAD	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.2222
p.T486A	TCGA-A5-A0VP	UCEC	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.825
p.K112N	TCGA-AA-A010	COAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2778
p.K112N	TCGA-B5-A1MR	UCEC	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2778
p.K112N	DO41758	UCEC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2778
p.T743A	TCGA-AP-A056	UCEC	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7139
p.T743A	DO43971	UCEC	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7139
p.T350S	TCGA-B5-A0K6	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.T350S	DO40808	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.R333Q	TCGA-B5-A3FC	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.R333Q	TCGA-FW-A3R5	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.R333Q	DO37406	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.R333Q	DO41871	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.P478L	TCGA-BR-8361	STAD	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.1389
p.R120H	TCGA-BR-8591	STAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.8244
p.R120H	DO47973	STAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.8244
p.K118T	TCGA-CA-6717	COAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.7306
p.K118T	TCGA-D9-A6EC	SKCM	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.7306
p.K118T	DO8264	COAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.7306
p.K118T	DO50291	SKCM	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.7306
p.A106S	TCGA-CR-7370	HNSC	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation substituting flanking lysine	0.2222
p.A106S	DO14426	HNSC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation substituting flanking lysine	0.2222
p.P105T	TCGA-D1-A16J	UCEC	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation substituting flanking lysine	0.1944
p.P105T	DO43033	UCEC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation substituting flanking lysine	0.1944
p.A733V	TCGA-D5-6530	COAD	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1667
p.P756H	TCGA-D5-6539	COAD	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0556
p.P756H	TCGA-DA-A1I1	SKCM	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0556
p.T742P	TCGA-D7-5579	STAD	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7031
p.S488G	TCGA-DM-A0XF	COAD	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.6993
p.S497F	TCGA-EE-A2A2	SKCM	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.1389
p.R344I	TCGA-EE-A2GN	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation altering degron motif	0.8102
p.R344I	DO37896	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation altering degron motif	0.8102
p.P483H	TCGA-EO-A3B0	UCEC	TCGA	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.2778
p.R333P	TCGA-EY-A2ON	UCEC	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.R333P	DO42849	UCEC	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.P339H	TCGA-FS-A1ZG	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.2778
p.P339H	DO37523	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.2778
p.P334H	TCGA-NJ-A4YQ	LUAD	TCGA	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1389
p.P334H	DO218944	LUAD	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1389
p.E476Q	DO856	BLCA	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.0833
p.E731K	DO225367	BRCA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1111
p.T481I	DO4401	BRCA	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation blocking phosphorylation signal	0.6667
p.T481I	DO43995	UCEC	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation blocking phosphorylation signal	0.6667
p.V734M	DO223732	CESC	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.T124P	DO233145	GACA	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.2778
p.S485C	DO233706	GACA	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.7541
p.P744Q	DO228978	LICA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7035
p.T736K	DO229018	LICA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.25
p.T736K	DO229045	LICA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.25
p.L494M	DO229037	LICA	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.2222
p.T755A	DO48681	LIRI	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.0833
p.R742K	DO220878	MELA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.7237
p.E485K	DO220886	MELA	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.7022
p.R120C	DO220886	MELA	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.8301
p.E731D	DO46657	PAAD	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1111
p.R751C	DO232761	PBCA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.G117S	DO229502	SKCA	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.6993
p.E476K	DO51278	SKCM	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.0833
p.R479G	DO38735	STAD	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.1667
p.R479G	DO48016	STAD	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.1667
p.T350A	DO229213	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.A353T	DO229240	THCA	ICGC	PTTSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1111
p.R744Q	DO43202	UCEC	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.6218
p.P482S	DO42608	UCEC	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.25
p.P482S	DO43755	UCEC	ICGC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.25
p.A115T	DO41331	UCEC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation altering degron motif	0.7139
p.S748P	SIDM00690	Head and Neck Carcinoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.2778
p.S748P	SIDM00863	Burkitt's Lymphoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.2778
p.S748P	SIDM01409	Bladder Carcinoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.2778
p.R475Q	SIDM00529	Breast Carcinoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation substituting flanking lysine	0.1667
p.G490R	SIDM00014	Colorectal Carcinoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.7568
p.G490R	SIDM00673	Breast Carcinoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.7568
p.G490R	SIDM01173	Rhabdomyosarcoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation altering degron motif	0.7568
p.P745T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.5919
p.P745T	ACH-000912	Lung Cancer	CCLE	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation altering degron motif	0.5919
p.R747T	ACH-000612	Lymphoma	CCLE	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.3056
p.R751H	ATN-1	haematopoietic and lymphoid tissue	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.R751H	GCIY	stomach	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.R751H	MKN1	stomach	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.R751H	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.R751H	TGW	autonomic ganglia	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.R751H	RKO	large intestine	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.R751H	KS-1	central nervous system	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.1944
p.A738S	HCT-15	large intestine	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.3056
p.R748L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	739:746	Mutation rewiring degron network	0.2778
p.S499I	HCT-15	large intestine	COSMIC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.0833
p.R104Q	A549	lung	COSMIC	SRKPLQLVV	DEG_APCC_DBOX_1	114:122	Mutation rewiring degron network	0.0556
p.P500A	LN-229	central nervous system	COSMIC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.0556
p.T498N	NCI-H1648	lung	COSMIC	ITPKIS	DEG_SCF_FBW7_1	485:490	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABI3BP

UniProt ID: Q7Z7G0

Entrez ID: 25890

Protein name: Target of Nesh-SH3 (Tarsh) (ABI gene family member 3-binding protein) (Nesh-binding protein) (NeshBP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABI3BP in