DegronMD

Uniprot ID: Q7Z7G0

Source protein: Target of Nesh-SH3

Source gene: ABI3BP

Class: DEG_SCF_FBW7_1

Location: 739:746

E3 ligase: FBXW7

DEGRON score: 0.9347

ASA_SCORE: 102.4375

COIL: 0.9576

CONS_SCORE: 0.3622

DSS_SCORE: 0.7825

HELIX: 0.0142

FCONS_SCORE: 0.7717

RIG_SCORE: 0.6176

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T743A	TCGA-AP-A056	UCEC	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	0.7139
p.T743A	DO43971	UCEC	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.7139
p.A733V	TCGA-D5-6530	COAD	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	0.1667
p.P756H	TCGA-D5-6539	COAD	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	0.0556
p.P756H	TCGA-DA-A1I1	SKCM	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	0.0556
p.T742P	TCGA-D7-5579	STAD	TCGA	LRSTPRPT	DEG_SCF_FBW7_1	0.7031
p.E731K	DO225367	BRCA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.1111
p.V734M	DO223732	CESC	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.P744Q	DO228978	LICA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.7035
p.T736K	DO229018	LICA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.25
p.T736K	DO229045	LICA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.25
p.T755A	DO48681	LIRI	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.0833
p.R742K	DO220878	MELA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.7237
p.E731D	DO46657	PAAD	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.1111
p.R751C	DO232761	PBCA	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R744Q	DO43202	UCEC	ICGC	LRSTPRPT	DEG_SCF_FBW7_1	0.6218
p.S748P	SIDM00690	Head and Neck Carcinoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	0.2778
p.S748P	SIDM00863	Burkitt's Lymphoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	0.2778
p.S748P	SIDM01409	Bladder Carcinoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	0.2778
p.P745T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	LRSTPRPT	DEG_SCF_FBW7_1	0.5919
p.P745T	ACH-000912	Lung Cancer	CCLE	LRSTPRPT	DEG_SCF_FBW7_1	0.5919
p.R747T	ACH-000612	Lymphoma	CCLE	LRSTPRPT	DEG_SCF_FBW7_1	0.3056
p.R751H	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R751H	GCIY	stomach	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R751H	MKN1	stomach	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R751H	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R751H	TGW	autonomic_ganglia	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R751H	RKO	large_intestine	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.R751H	KS-1	central_nervous_system	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.1944
p.A738S	HCT-15	large_intestine	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.3056
p.R748L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LRSTPRPT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRSTPRPT

Degron related mutations and impact score

Drug responses associated with ABI3BP mutations

All proteins holding degron of LRSTPRPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7G0	Target of Nesh-SH3	DEG_SCF_FBW7_1	739:746	LRSTPRPT	FBXW7	0.9347	More...