DegronMD

Uniprot ID: Q7Z7G0

Source protein: Target of Nesh-SH3

Source gene: ABI3BP

Class: DEG_SCF_FBW7_1

Location: 485:490

E3 ligase: FBXW7

DEGRON score: 0.9378

ASA_SCORE: 91.8667

COIL: 0.9528

CONS_SCORE: 0.2366

DSS_SCORE: 0.739

HELIX: 0.0137

FCONS_SCORE: 0.8731

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S499R	TCGA-13-1497	OV	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.0833
p.P494T	TCGA-91-A4BC	LUAD	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.2222
p.T486A	TCGA-A5-A0VP	UCEC	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.825
p.P478L	TCGA-BR-8361	STAD	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.1389
p.S488G	TCGA-DM-A0XF	COAD	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.6993
p.S497F	TCGA-EE-A2A2	SKCM	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.1389
p.P483H	TCGA-EO-A3B0	UCEC	TCGA	ITPKIS	DEG_SCF_FBW7_1	0.2778
p.E476Q	DO856	BLCA	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.0833
p.T481I	DO4401	BRCA	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.6667
p.T481I	DO43995	UCEC	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.6667
p.S485C	DO233706	GACA	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.7541
p.L494M	DO229037	LICA	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.2222
p.E485K	DO220886	MELA	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.7022
p.E476K	DO51278	SKCM	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.0833
p.R479G	DO38735	STAD	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.1667
p.R479G	DO48016	STAD	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.1667
p.P482S	DO42608	UCEC	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.25
p.P482S	DO43755	UCEC	ICGC	ITPKIS	DEG_SCF_FBW7_1	0.25
p.R475Q	SIDM00529	Breast Carcinoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	0.1667
p.G490R	SIDM00014	Colorectal Carcinoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	0.7568
p.G490R	SIDM00673	Breast Carcinoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	0.7568
p.G490R	SIDM01173	Rhabdomyosarcoma	GDSC	ITPKIS	DEG_SCF_FBW7_1	0.7568
p.S499I	HCT-15	large_intestine	COSMIC	ITPKIS	DEG_SCF_FBW7_1	0.0833
p.P500A	LN-229	central_nervous_system	COSMIC	ITPKIS	DEG_SCF_FBW7_1	0.0556
p.T498N	NCI-H1648	lung	COSMIC	ITPKIS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7G0	Target of Nesh-SH3	DEG_SCF_FBW7_1	485:490	ITPKIS	FBXW7	0.9378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons