DegronMD

Uniprot ID: Q7Z7G0

Source protein: Target of Nesh-SH3

Source gene: ABI3BP

Class: DEG_APCC_DBOX_1

Location: 114:122

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5878

ASA_SCORE: 74.3444

COIL: 0.6013

CONS_SCORE: 0.4621

DSS_SCORE: 0.409

HELIX: 0.0341

FCONS_SCORE: 1.0282

RIG_SCORE: 0.7779

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R120L	TCGA-86-8358	LUAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.8428
p.R120L	DO25471	LUAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.8428
p.R120C	DO220886	MELA	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.8301
p.R120H	TCGA-BR-8591	STAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.8244
p.R120H	DO47973	STAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.8244
p.K118T	TCGA-CA-6717	COAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.7306
p.K118T	TCGA-D9-A6EC	SKCM	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.7306
p.K118T	DO8264	COAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.7306
p.K118T	DO50291	SKCM	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.7306
p.A115T	DO41331	UCEC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.7139
p.G117S	DO229502	SKCA	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.6993
p.K112N	TCGA-AA-A010	COAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.2778
p.K112N	TCGA-B5-A1MR	UCEC	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.2778
p.K112N	DO41758	UCEC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.2778
p.T124P	DO233145	GACA	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.2778
p.A106S	TCGA-CR-7370	HNSC	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.2222
p.A106S	DO14426	HNSC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.2222
p.P105T	TCGA-D1-A16J	UCEC	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.1944
p.P105T	DO43033	UCEC	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.1944
p.R104L	TCGA-55-8203	LUAD	TCGA	SRKPLQLVV	DEG_APCC_DBOX_1	0.0556
p.R104L	DO218928	LUAD	ICGC	SRKPLQLVV	DEG_APCC_DBOX_1	0.0556
p.R104Q	A549	lung	COSMIC	SRKPLQLVV	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7G0	Target of Nesh-SH3	DEG_APCC_DBOX_1	114:122	SRKPLQLVV	APC,CDC20,FZR1	0.5878	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons