DegronMD - Q15915(ZIC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P417T	TCGA-25-1319	OV	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7031
p.P417T	DO233893	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7031
p.P417T	DO32526	OV	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7031
p.S411F	TCGA-BT-A20J	BLCA	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1667
p.S411F	DO457	BLCA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1667
p.S426F	TCGA-D3-A8GI	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S426F	TCGA-EE-A2M6	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S426F	DO222514	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S426F	DO50284	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S426F	DO37976	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S425P	TCGA-G4-6309	COAD	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2222
p.S425P	DO7810	COAD	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2222
p.S425P	DO227906	COCA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2222
p.T419K	TCGA-L3-A524	LUSC	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7306
p.T419K	DO45476	LUSC	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7306
p.P417L	TCGA-Z2-A8RT	SKCM	TCGA	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7582
p.P417L	DO51301	SKCM	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation altering degron motif	0.7582
p.T414K	DO228131	EOPC	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25
p.D415E	DO233171	GACA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2778
p.H430N	DO23164	LINC	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0833
p.S423L	DO220881	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2778
p.S423L	DO224719	PACA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2778
p.S413F	DO222908	MELA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.2222
p.T408P	DO35571	PBCA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0833
p.P407T	DO230449	UTCA	ICGC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.0556
p.L422I	SIDM00698	Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.L422I	ACH-000506	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.L422I	NCI-H146	lung	COSMIC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.3056
p.S426T	SIDM00282	Colorectal Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S426T	ACH-000998	Colon/Colorectal Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.S426T	CW-2	large intestine	COSMIC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1944
p.I409M	SIDM00861	Ovarian Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1111
p.I409M	ACH-000906	Ovarian Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1111
p.I409M	ES-2	ovary	COSMIC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.1111
p.P424L	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25
p.P424L	ACH-000925	Lung Cancer	CCLE	PTTSS	DEG_SPOP_SBC_1	417:421	Mutation rewiring degron network	0.25

Kaplan plot for ZIC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZIC1

UniProt ID: Q15915

Entrez ID: 7545

Protein name: Zinc finger protein ZIC 1 (Zinc finger protein 201) (Zinc finger protein of the cerebellum 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZIC1 in