DegronMD

Uniprot ID: P78312

Source protein: Protein FAM193A

Source gene: FAM193A

Class: DEG_SCF_TRCP1_1

Location: 284:290

E3 ligase: BTRC

DEGRON score: 0.9974

ASA_SCORE: 71.1714

COIL: 0.9051

CONS_SCORE: 0.3752

DSS_SCORE: 0.5088

HELIX: 0.0256

FCONS_SCORE: 0.6368

RIG_SCORE: 0.6651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D295N	TCGA-AJ-A3TW	UCEC	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	0.1944
p.D295N	DO43723	UCEC	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	0.1944
p.P278S	TCGA-AP-A1DK	UCEC	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	0.1667
p.P278S	DO42033	UCEC	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	0.1667
p.A288T	TCGA-CV-A461	HNSC	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	0.6028
p.A288T	DO49058	HNSC	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	0.6028
p.P300Q	TCGA-D3-A2J6	SKCM	TCGA	DSGSAPT	DEG_SCF_TRCP1_1	0.0556
p.P300Q	DO37901	SKCM	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	0.0556
p.S287L	DO233259	GACA	ICGC	DSGSAPT	DEG_SCF_TRCP1_1	0.7667
p.A288V	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DSGSAPT	DEG_SCF_TRCP1_1	0.5825
p.A288V	NCI-H1563	lung	COSMIC	DSGSAPT	DEG_SCF_TRCP1_1	0.5825
p.P281S	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGSAPT	DEG_SCF_TRCP1_1	0.25
p.P281S	HCT-116	large_intestine	COSMIC	DSGSAPT	DEG_SCF_TRCP1_1	0.25
p.S288L	EVSA-T	breast	COSMIC	DSGSAPT	DEG_SCF_TRCP1_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78312	Protein FAM193A	DEG_SCF_TRCP1_1	284:290	DSGSAPT	BTRC	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons