DegronMD

Uniprot ID: P78312

Source protein: Protein FAM193A

Source gene: FAM193A

Class: DEG_SCF_FBW7_1

Location: 476:483

E3 ligase: FBXW7

DEGRON score: 0.9846

ASA_SCORE: 93.75

COIL: 0.9535

CONS_SCORE: 0.6689

DSS_SCORE: 0.4262

HELIX: 0.0226

FCONS_SCORE: 0.9623

RIG_SCORE: 0.7006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P489L	TCGA-37-4130	LUSC	TCGA	LYATPPFT	DEG_SCF_FBW7_1	0.1667
p.P489L	DO228187	LICA	ICGC	LYATPPFT	DEG_SCF_FBW7_1	0.1667
p.P489L	DO26490	LUSC	ICGC	LYATPPFT	DEG_SCF_FBW7_1	0.1667
p.P489L	SIDM00983	Bladder Carcinoma	GDSC	LYATPPFT	DEG_SCF_FBW7_1	0.1667
p.P489L	647-V	urinary_tract	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.1667
p.P474H	TCGA-D5-6927	COAD	TCGA	LYATPPFT	DEG_SCF_FBW7_1	0.2778
p.P474H	DO10332	COAD	ICGC	LYATPPFT	DEG_SCF_FBW7_1	0.2778
p.S485I	TCGA-DF-A2KU	UCEC	TCGA	LYATPPFT	DEG_SCF_FBW7_1	0.2778
p.S485I	DO223286	UCEC	ICGC	LYATPPFT	DEG_SCF_FBW7_1	0.2778
p.R469H	TCGA-G4-6304	COAD	TCGA	LYATPPFT	DEG_SCF_FBW7_1	0.1389
p.R469H	DO10639	COAD	ICGC	LYATPPFT	DEG_SCF_FBW7_1	0.1389
p.R469H	SIDM00352	Ovarian Carcinoma	GDSC	LYATPPFT	DEG_SCF_FBW7_1	0.1389
p.R469H	RMG-I	ovary	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.1389
p.P481R	SIDM00942	Oral Cavity Carcinoma	GDSC	LYATPPFT	DEG_SCF_FBW7_1	0.6401
p.P481R	CAL-33	upper_aerodigestive_tract	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.6401
p.R491H	ACH-000719	Ovarian Cancer	CCLE	LYATPPFT	DEG_SCF_FBW7_1	0.1111
p.R491H	RMG-I	ovary	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.1111
p.T467I	ACH-000985	Colon/Colorectal Cancer	CCLE	LYATPPFT	DEG_SCF_FBW7_1	0.0833
p.T467I	LS-411N	large_intestine	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.0833
p.H468Y	ACH-002256	Leukemia	CCLE	LYATPPFT	DEG_SCF_FBW7_1	0.1111
p.H468Y	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.1111
p.M490I	KARPAS-231	haematopoietic_and_lymphoid_tissue	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.1389
p.A469T	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LYATPPFT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78312	Protein FAM193A	DEG_SCF_FBW7_1	476:483	LYATPPFT	FBXW7	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons