DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTPFGS
Uniprot ID:
Q2KHR2
Source protein:
DNA-binding protein RFX7
Source gene:
RFX7
Class:
DEG_SCF_FBW7_1
Location:
1096:1101
E3 ligase:
FBXW7
DEGRON score:
0.997
ASA_SCORE:
84.2
COIL:
0.9365
CONS_SCORE:
0.3807
DSS_SCORE:
0.4206
HELIX:
0.0167
FCONS_SCORE:
0.9871
RIG_SCORE:
0.6672
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q1087L
TCGA-44-A479
LUAD
TCGA
VTPFGS
DEG_SCF_FBW7_1
0.0833
p.F1094V
TCGA-EO-A3B0
UCEC
TCGA
VTPFGS
DEG_SCF_FBW7_1
0.2778
p.P1103T
TCGA-UZ-A9PX
KIRP
TCGA
VTPFGS
DEG_SCF_FBW7_1
0.2778
p.T1097N
DO8594
COAD
ICGC
VTPFGS
DEG_SCF_FBW7_1
0.8166
p.P1087L
DO37583
SKCM
ICGC
VTPFGS
DEG_SCF_FBW7_1
0.0833
p.S1094Y
DO42320
UCEC
ICGC
VTPFGS
DEG_SCF_FBW7_1
0.2778
p.S1094Y
DO43186
UCEC
ICGC
VTPFGS
DEG_SCF_FBW7_1
0.2778
p.P1087S
DO42977
UCEC
ICGC
VTPFGS
DEG_SCF_FBW7_1
0.0833
Drug responses associated with RFX7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPFGS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2KHR2
DNA-binding protein RFX7
DEG_SCF_FBW7_1
1096:1101
VTPFGS
FBXW7
0.997
More...