DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_SCF_FBW7_1

Location: 855:862

E3 ligase: FBXW7

DEGRON score: 0.6984

ASA_SCORE: 107.1

COIL: 0.9818

CONS_SCORE: 0.4059

DSS_SCORE: 0.8393

HELIX: 0.0054

FCONS_SCORE: 0.973

RIG_SCORE: 0.5441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N872D	TCGA-21-1080	LUSC	TCGA	PTPTPTPT	DEG_SCF_FBW7_1	0.0556
p.N845H	TCGA-A5-A2K5	UCEC	TCGA	PTPTPTPT	DEG_SCF_FBW7_1	0.0556
p.Q846K	TCGA-E6-A1LX	UCEC	TCGA	PTPTPTPT	DEG_SCF_FBW7_1	0.0833
p.M871L	DO50092	COAD	ICGC	PTPTPTPT	DEG_SCF_FBW7_1	0.0833
p.T846N	DO228921	LICA	ICGC	PTPTPTPT	DEG_SCF_FBW7_1	0.0833
p.P859L	SIDM01629	Melanoma	GDSC	PTPTPTPT	DEG_SCF_FBW7_1	0.6471
p.P859L	ACH-000404	Skin Cancer	CCLE	PTPTPTPT	DEG_SCF_FBW7_1	0.6471
p.P859S	SIDM01629	Melanoma	GDSC	PTPTPTPT	DEG_SCF_FBW7_1	0.5641
p.P859S	ACH-000404	Skin Cancer	CCLE	PTPTPTPT	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR2	DNA-binding protein RFX7	DEG_SCF_FBW7_1	855:862	PTPTPTPT	FBXW7	0.6984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons