DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_SCF_FBW7_1

Location: 847:854

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 105.8875

COIL: 0.9778

CONS_SCORE: 0.4533

DSS_SCORE: 0.7859

HELIX: 0.0058

FCONS_SCORE: 1.1088

RIG_SCORE: 0.5536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N845H	TCGA-A5-A2K5	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	0.2778
p.S851Y	TCGA-AX-A05Z	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	0.712
p.S851Y	TCGA-B5-A11E	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	0.712
p.Q846K	TCGA-E6-A1LX	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	0.3056
p.D853N	TCGA-EY-A215	UCEC	TCGA	PIHTPTPT	DEG_SCF_FBW7_1	0.6932
p.T852I	DO5060	BRCA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	0.5966
p.T846N	DO228921	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	0.3056
p.P853H	DO228948	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	0.6583
p.P853H	DO228950	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	0.6583
p.P851H	DO228950	LICA	ICGC	PIHTPTPT	DEG_SCF_FBW7_1	0.7694
p.I848V	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PIHTPTPT	DEG_SCF_FBW7_1	0.5965
p.I848V	ACH-000563	Lung Cancer	CCLE	PIHTPTPT	DEG_SCF_FBW7_1	0.5965
p.I848V	EBC-1	lung	COSMIC	PIHTPTPT	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR2	DNA-binding protein RFX7	DEG_SCF_FBW7_1	847:854	PIHTPTPT	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons