DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: LIG_APCC_ABBAyCdc20_2

Location: 29:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9573

ASA_SCORE: 69.5429

COIL: 0.168

CONS_SCORE: 0.8951

DSS_SCORE: 0.343

HELIX: 0.815

FCONS_SCORE: 1.2596

RIG_SCORE: 0.8046

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L33F	TCGA-D6-6516	HNSC	TCGA	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L33F	DO15623	HNSC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.6981
p.N25S	TCGA-F2-A7TX	PAAD	TCGA	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N25S	DO50254	PAAD	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E24K	DO6338	CESC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P28S	DO10276	COAD	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y39H	DO8264	COAD	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P23L	DO12946	GBM	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S38C	DO16269	KIRC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.25
p.P35T	DO229018	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.7031
p.H22N	DO229032	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.H22N	DO229036	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.Q30K	DO229037	LICA	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.5833
p.L19I	DO47491	SKCM	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L43I	DO41020	UCEC	ICGC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D34N	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D34N	ACH-000878	Lung Cancer	CCLE	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.D34N	HCC-15	lung	COSMIC	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.5821
p.P38T	ACH-000971	Colon/Colorectal Cancer	CCLE	KQEVYDE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR2	DNA-binding protein RFX7	LIG_APCC_ABBAyCdc20_2	29:35	KQEVYDE	APC,CDC20,FZR1	0.9573	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons