DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_SCF_FBW7_1

Location: 381:388

E3 ligase: FBXW7

DEGRON score: 0.9955

ASA_SCORE: 95.075

COIL: 0.9588

CONS_SCORE: 0.4033

DSS_SCORE: 0.4597

HELIX: 0.0212

FCONS_SCORE: 0.9227

RIG_SCORE: 0.6825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G388D	TCGA-AX-A06F	UCEC	TCGA	ISLTPSNS	DEG_SCF_FBW7_1	0.7198
p.S385Y	TCGA-EO-A3AV	UCEC	TCGA	ISLTPSNS	DEG_SCF_FBW7_1	0.712
p.I381V	DO51603	CESC	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	0.5965
p.V376A	DO9346	COAD	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	0.1944
p.T390P	DO27779	MALY	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	0.2778
p.S382F	DO229459	SKCA	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	0.6871
p.T379A	DO41235	UCEC	ICGC	ISLTPSNS	DEG_SCF_FBW7_1	0.2778
p.V375M	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ISLTPSNS	DEG_SCF_FBW7_1	0.1667
p.V375M	ACH-000636	Leukemia	CCLE	ISLTPSNS	DEG_SCF_FBW7_1	0.1667
p.V375M	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	ISLTPSNS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR2	DNA-binding protein RFX7	DEG_SCF_FBW7_1	381:388	ISLTPSNS	FBXW7	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons