DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_SCF_FBW7_1

Location: 863:868

E3 ligase: FBXW7

DEGRON score: 0.6646

ASA_SCORE: 87.5167

COIL: 0.96

CONS_SCORE: 0.3679

DSS_SCORE: 0.8124

HELIX: 0.0158

FCONS_SCORE: 0.9403

RIG_SCORE: 0.6135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N872D	TCGA-21-1080	LUSC	TCGA	PTPTPT	DEG_SCF_FBW7_1	0.2222
p.E873K	TCGA-ZJ-A8QR	CESC	TCGA	PTPTPT	DEG_SCF_FBW7_1	0.1944
p.M871L	DO50092	COAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.25
p.P867L	DO8312	COAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.6471
p.P867L	DO228542	GACA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.6471
p.A873D	DO228948	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.1944
p.P865Q	DO228971	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.7035
p.T868K	DO228986	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.7306
p.T868K	DO229031	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.7306
p.T864I	DO52402	UCEC	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons