DegronMD

Uniprot ID: P40225

Source protein: Thrombopoietin

Source gene: THPO

Class: DEG_SCF_FBW7_1

Location: 330:335

E3 ligase: FBXW7

DEGRON score: 0.8777

ASA_SCORE: 88.0167

COIL: 0.9558

CONS_SCORE: 0.438

DSS_SCORE: 0.6872

HELIX: 0.015

FCONS_SCORE: 0.8417

RIG_SCORE: 0.5967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L338F	TCGA-78-8662	LUAD	TCGA	PTPTPT	DEG_SCF_FBW7_1	0.25
p.L338F	DO45346	LUAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.25
p.T331M	TCGA-BR-4292	STAD	TCGA	PTPTPT	DEG_SCF_FBW7_1	0.7423
p.T331M	DO38495	STAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.7423
p.H345Q	DO229029	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.0556
p.H345Q	SIDM01036	Plasma Cell Myeloma	GDSC	PTPTPT	DEG_SCF_FBW7_1	0.0556
p.H345Q	ACH-000653	Myeloma	CCLE	PTPTPT	DEG_SCF_FBW7_1	0.0556
p.H345Q	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPT	DEG_SCF_FBW7_1	0.0556
p.P330S	DO27943	ORCA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.6752
p.Y343D	DO46933	RECA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.1111
p.P330L	DO218861	SKCA	ICGC	PTPTPT	DEG_SCF_FBW7_1	0.6471
p.T344A	SIDM00087	Plasma Cell Myeloma	GDSC	PTPTPT	DEG_SCF_FBW7_1	0.0833
p.T344A	SIDM00863	Burkitt's Lymphoma	GDSC	PTPTPT	DEG_SCF_FBW7_1	0.0833
p.T344A	SIDM00808	Burkitt's Lymphoma	GDSC	PTPTPT	DEG_SCF_FBW7_1	0.0833
p.T344A	SIDM01254	Burkitt's Lymphoma	GDSC	PTPTPT	DEG_SCF_FBW7_1	0.0833
p.P325S	ACH-001791	Liposarcoma	CCLE	PTPTPT	DEG_SCF_FBW7_1	0.1944
p.H341Q	JJN-3	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTPT	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons