DegronMD - P40225(THPO)

FUNCTION: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

GO - Biological processes (BP): cell population proliferation [GO:0008283]; cellular response to lipopolysaccharide [GO:0071222]; megakaryocyte development [GO:0035855]; multicellular organism development [GO:0007275]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [... View more >>

GO - Molecular function (MF): cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]

GO - Cellular component (CC): extracellular region [GO:0005576]; extracellular space [GO:0005615]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
NLQPGYSPSP	CBL_PTK	CBL	Thrombopoietin	287:296	More..
PTPTPT	DEG_SCF_FBW7_1	FBXW7	Thrombopoietin	330:335	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T331M	TCGA-BR-4292	STAD	TCGA	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.7423
p.T331M	DO38495	STAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.7423
p.P330S	DO27943	ORCA	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.6752
p.P330L	DO218861	SKCA	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.6471
p.P290S	TCGA-LN-A4A9	ESCA	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation altering degron motif	0.5641
p.P286L	TCGA-D3-A8GM	SKCM	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	DO50288	SKCM	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	SIDM00140	Melanoma	GDSC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	ACH-000968	Skin Cancer	CCLE	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	COLO-792	skin	COSMIC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P285L	SIDM01765	Osteosarcoma	GDSC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2778
p.P285L	ACH-000529	Non-Cancerous	CCLE	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2778
p.L338F	TCGA-78-8662	LUAD	TCGA	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.25
p.L338F	DO45346	LUAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.25
p.P299L	TCGA-D1-A103	UCEC	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.25
p.P299L	DO42312	UCEC	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.25
p.S283Y	TCGA-MV-A51V	BLCA	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2222
p.S283Y	DO474	BLCA	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2222
p.G282S	TCGA-IB-7651	PAAD	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.1944
p.P325S	ACH-001791	Liposarcoma	CCLE	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 37 entries

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No resistance data available for this Degron.

Kaplan plot for THPO in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

THPO

UniProt ID: P40225

Entrez ID: 7066

Protein name: Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for THPO in