DegronMD - P40225(THPO)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L338F	TCGA-78-8662	LUAD	TCGA	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.25
p.L338F	DO45346	LUAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.25
p.T305M	TCGA-A6-6780	COAD	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.0833
p.T305M	DO10244	COAD	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.0833
p.T331M	TCGA-BR-4292	STAD	TCGA	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.7423
p.T331M	DO38495	STAD	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.7423
p.P299L	TCGA-D1-A103	UCEC	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.25
p.P299L	DO42312	UCEC	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.25
p.P286L	TCGA-D3-A8GM	SKCM	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	DO50288	SKCM	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	SIDM00140	Melanoma	GDSC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	ACH-000968	Skin Cancer	CCLE	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.P286L	COLO-792	skin	COSMIC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.3056
p.G282S	TCGA-IB-7651	PAAD	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.1944
p.P290S	TCGA-LN-A4A9	ESCA	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation altering degron motif	0.5641
p.S283Y	TCGA-MV-A51V	BLCA	TCGA	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2222
p.S283Y	DO474	BLCA	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2222
p.G277E	DO228974	LICA	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.0556
p.H345Q	DO229029	LICA	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0556
p.H345Q	SIDM01036	Plasma Cell Myeloma	GDSC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0556
p.H345Q	ACH-000653	Myeloma	CCLE	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0556
p.H345Q	JJN-3	haematopoietic and lymphoid tissue	COSMIC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0556
p.P330S	DO27943	ORCA	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.6752
p.Y343D	DO46933	RECA	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.1111
p.P330L	DO218861	SKCA	ICGC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation altering degron motif	0.6471
p.P277S	DO41999	UCEC	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.0556
p.A281V	DO42673	UCEC	ICGC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.1667
p.T344A	SIDM00087	Plasma Cell Myeloma	GDSC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0833
p.T344A	SIDM00863	Burkitt's Lymphoma	GDSC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0833
p.T344A	SIDM00808	Burkitt's Lymphoma	GDSC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0833
p.T344A	SIDM01254	Burkitt's Lymphoma	GDSC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.0833
p.P285L	SIDM01765	Osteosarcoma	GDSC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2778
p.P285L	ACH-000529	Non-Cancerous	CCLE	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.2778
p.P325S	ACH-001791	Liposarcoma	CCLE	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.1944
p.H341Q	JJN-3	haematopoietic and lymphoid tissue	COSMIC	PTPTPT	DEG_SCF_FBW7_1	330:335	Mutation rewiring degron network	0.1667
p.P282L	COLO-792	skin	COSMIC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.1944
p.P277L	SISO	cervix	COSMIC	NLQPGYSPSP	CBL_PTK	287:296	Mutation rewiring degron network	0.0556

Kaplan plot for THPO in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THPO

UniProt ID: P40225

Entrez ID: 7066

Protein name: Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for THPO in