DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NLQPGYSPSP
Uniprot ID:
P40225
Source protein:
Thrombopoietin
Source gene:
THPO
Class:
CBL_PTK
Location:
287:296
E3 ligase:
CBL
DEGRON score:
0.9935
ASA_SCORE:
76.2
COIL:
0.9407
CONS_SCORE:
0.752
DSS_SCORE:
0.7662
HELIX:
0.0177
FCONS_SCORE:
1.0441
RIG_SCORE:
0.5236
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T305M
TCGA-A6-6780
COAD
TCGA
NLQPGYSPSP
CBL_PTK
0.0833
p.T305M
DO10244
COAD
ICGC
NLQPGYSPSP
CBL_PTK
0.0833
p.P299L
TCGA-D1-A103
UCEC
TCGA
NLQPGYSPSP
CBL_PTK
0.25
p.P299L
DO42312
UCEC
ICGC
NLQPGYSPSP
CBL_PTK
0.25
p.P286L
TCGA-D3-A8GM
SKCM
TCGA
NLQPGYSPSP
CBL_PTK
0.3056
p.P286L
DO50288
SKCM
ICGC
NLQPGYSPSP
CBL_PTK
0.3056
p.P286L
SIDM00140
Melanoma
GDSC
NLQPGYSPSP
CBL_PTK
0.3056
p.P286L
ACH-000968
Skin Cancer
CCLE
NLQPGYSPSP
CBL_PTK
0.3056
p.P286L
COLO-792
skin
COSMIC
NLQPGYSPSP
CBL_PTK
0.3056
p.G282S
TCGA-IB-7651
PAAD
TCGA
NLQPGYSPSP
CBL_PTK
0.1944
p.P290S
TCGA-LN-A4A9
ESCA
TCGA
NLQPGYSPSP
CBL_PTK
0.5641
p.S283Y
TCGA-MV-A51V
BLCA
TCGA
NLQPGYSPSP
CBL_PTK
0.2222
p.S283Y
DO474
BLCA
ICGC
NLQPGYSPSP
CBL_PTK
0.2222
p.G277E
DO228974
LICA
ICGC
NLQPGYSPSP
CBL_PTK
0.0556
p.P277S
DO41999
UCEC
ICGC
NLQPGYSPSP
CBL_PTK
0.0556
p.A281V
DO42673
UCEC
ICGC
NLQPGYSPSP
CBL_PTK
0.1667
p.P285L
SIDM01765
Osteosarcoma
GDSC
NLQPGYSPSP
CBL_PTK
0.2778
p.P285L
ACH-000529
Non-Cancerous
CCLE
NLQPGYSPSP
CBL_PTK
0.2778
p.P282L
COLO-792
skin
COSMIC
NLQPGYSPSP
CBL_PTK
0.1944
p.P277L
SISO
cervix
COSMIC
NLQPGYSPSP
CBL_PTK
0.0556
Drug responses associated with THPO mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NLQPGYSPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P40225
Thrombopoietin
CBL_PTK
287:296
NLQPGYSPSP
CBL
0.9935
More...
