DegronMD

Uniprot ID: Q2KHR2

Source protein: DNA-binding protein RFX7

Source gene: RFX7

Class: DEG_APCC_DBOX_1

Location: 1182:1190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8492

ASA_SCORE: 86.1778

COIL: 0.6441

CONS_SCORE: 0.4615

DSS_SCORE: 0.3789

HELIX: 0.1666

FCONS_SCORE: 1.2153

RIG_SCORE: 0.7947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1194N	TCGA-A6-2675	COAD	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	0.2222
p.S1191Y	TCGA-AP-A1DV	UCEC	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	0.3056
p.S1191Y	TCGA-EO-A22T	UCEC	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	0.3056
p.P1184S	TCGA-BG-A222	UCEC	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	0.6752
p.P1184L	TCGA-EE-A2A2	SKCM	TCGA	ARMNLTQIL	DEG_APCC_DBOX_1	0.7582
p.R1183W	DO222765	COCA	ICGC	ARMNLTQIL	DEG_APCC_DBOX_1	0.8634
p.I1189M	DO36556	READ	ICGC	ARMNLTQIL	DEG_APCC_DBOX_1	0.6507
p.P1197S	DO51761	STAD	ICGC	ARMNLTQIL	DEG_APCC_DBOX_1	0.1389
p.T1194P	SIDM00845	Burkitt's Lymphoma	GDSC	ARMNLTQIL	DEG_APCC_DBOX_1	0.2222
p.T1194P	ACH-000786	Lymphoma	CCLE	ARMNLTQIL	DEG_APCC_DBOX_1	0.2222
p.T1194P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARMNLTQIL	DEG_APCC_DBOX_1	0.2222
p.N1200S	SIDM00294	Small Cell Lung Carcinoma	GDSC	ARMNLTQIL	DEG_APCC_DBOX_1	0.0556
p.N1200S	ACH-001549	Lung Cancer	CCLE	ARMNLTQIL	DEG_APCC_DBOX_1	0.0556
p.N1200S	LU-135	lung	COSMIC	ARMNLTQIL	DEG_APCC_DBOX_1	0.0556
p.P1192T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARMNLTQIL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR2	DNA-binding protein RFX7	DEG_APCC_DBOX_1	1182:1190	ARMNLTQIL	APC,CDC20,FZR1	0.8492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons