DegronMD

Uniprot ID: Q96G46

Source protein: tRNA-dihydrouridine

Source gene: DUS3L

Class: DEG_SPOP_SBC_1

Location: 269:273

E3 ligase: SPOP

DEGRON score: 0.9172

ASA_SCORE: 82.56

COIL: 0.9558

CONS_SCORE: 0.145

DSS_SCORE: 0.711

HELIX: 0.011

FCONS_SCORE: 0.8492

RIG_SCORE: 0.5038

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A267V	TCGA-86-A4JF	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.2778
p.A267V	DO45317	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.2778
p.A267V	DO48177	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.2778
p.A267S	TCGA-86-A4JF	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.2778
p.A267S	DO45317	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.2778
p.P278R	TCGA-BS-A0UV	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1944
p.P278R	DO42793	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.G268W	TCGA-GN-A4U5	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.3056
p.G268W	DO51257	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.3056
p.M268L	DO44400	CESC	ICGC	PGTST	DEG_SPOP_SBC_1	0.3056
p.R266C	DO234362	ESAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.A281V	DO233652	GACA	ICGC	PGTST	DEG_SPOP_SBC_1	0.5556
p.R279S	DO14278	HNSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.R279S	DO37515	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.R279S	DO38328	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.R279C	DO219125	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.G280D	DO46657	PAAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.R266S	DO37515	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.G274W	DO37794	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.3056
p.R279L	DO37971	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.Q269H	DO229234	THCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.7582
p.T273A	DO42023	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.825
p.T273I	SIDM01293	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.8189
p.V279M	SIDM00656	Burkitt's Lymphoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1667
p.V279M	SIDM00954	Breast Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1667
p.V279M	SIDM00641	Burkitt's Lymphoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1667
p.A262S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1389
p.A262S	ACH-000929	Lung Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.1389
p.A262S	NCI-H2110	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	0.1389
p.C260Y	ACH-001289	Rhabdoid	CCLE	PGTST	DEG_SPOP_SBC_1	0.0833
p.R280Q	ACH-001863	Bile Duct Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.1389
p.M276V	SW48	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with DUS3L mutations

All proteins holding degron of PGTST