DegronMD - P24592(IGFBP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G142D	TCGA-AX-A06F	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.6087
p.S152Y	TCGA-BS-A0UF	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1389
p.R139K	TCGA-EB-A6R0	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2778
p.A153T	TCGA-YL-A8SB	PRAD	TCGA	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1111
p.A151T	DO11854	GBM	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1667
p.A151T	DO51426	PRAD	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1667
p.R137K	DO220887	MELA	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2222
p.R137K	DO48646	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2222
p.V153A	DO46438	OV	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1111
p.V153F	DO46438	OV	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1111
p.G140D	DO41752	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.3056
p.S150Y	DO41488	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1944
p.S148F	SIDM00790	Non-Cancerous	GDSC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.S148F	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.25
p.P141S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.6752
p.P141S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation altering degron motif	0.6752
p.D136G	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1944
p.D155N	ACH-000522	Bladder Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0556
p.D155N	UM-UC-3	urinary tract	COSMIC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.0556
p.D134G	ACH-000942	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1389
p.P150S	ACH-000995	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.1944
p.P139S	ACH-001127	Leukemia	CCLE	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2778
p.P139S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	141:145	Mutation rewiring degron network	0.2778

Kaplan plot for IGFBP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGFBP6

UniProt ID: P24592

Entrez ID: 3489

Protein name: Insulin-like growth factor-binding protein 6 (IBP-6) (IGF-binding protein 6) (IGFBP-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGFBP6 in