DegronMD - Q86X27(RALGPS2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D276Y	TCGA-A5-A0G2	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.D276Y	DO41235	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.A380V	TCGA-BR-4184	STAD	TCGA	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1667
p.A380V	DO38328	STAD	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1667
p.R297I	TCGA-D3-A2JC	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1389
p.R297I	DO47578	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1389
p.E387K	TCGA-IR-A3LI	CESC	TCGA	AESST	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.591
p.E387K	DO44400	CESC	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.591
p.P378L	TCGA-VR-A8EX	ESCA	TCGA	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1111
p.A295S	DO224905	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.1944
p.R292C	DO222955	BTCA	ICGC	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.2778
p.G394E	DO233766	GACA	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2222
p.R383Q	DO233869	GACA	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.R383L	DO228925	LICA	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.A380S	DO229038	LICA	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1667
p.L300S	DO50913	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	286:290	Mutation rewiring degron network	0.0556
p.G384C	DO50906	LICA	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.S393G	DO23360	LINC	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.S392F	DO23360	LINC	ICGC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2778
p.Q385K	SIDM00789	Colorectal Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.Q385K	ACH-000997	Colon/Colorectal Cancer	CCLE	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.Q385K	ACH-001061	Colon/Colorectal Cancer	CCLE	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056
p.Q385K	HCT-15	large intestine	COSMIC	AESST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.3056

Kaplan plot for RALGPS2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALGPS2

UniProt ID: Q86X27

Entrez ID: 55103

Protein name: Ras-specific guanine nucleotide-releasing factor RalGPS2 (Ral GEF with PH domain and SH3-binding motif 2) (RalA exchange factor RalGPS2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RALGPS2 in