DegronMD

Uniprot ID: Q86X27

Source protein: Ras-specific guanine nucleotide-releasing factor RalGPS2

Source gene: RALGPS2

Class: DEG_SPOP_SBC_1

Location: 386:390

E3 ligase: SPOP

DEGRON score: 0.9787

ASA_SCORE: 67.4

COIL: 0.7034

CONS_SCORE: 0.4653

DSS_SCORE: 0.6518

HELIX: 0.1654

FCONS_SCORE: 1.0191

RIG_SCORE: 0.6078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A380V	TCGA-BR-4184	STAD	TCGA	AESST	DEG_SPOP_SBC_1	0.1667
p.A380V	DO38328	STAD	ICGC	AESST	DEG_SPOP_SBC_1	0.1667
p.E387K	TCGA-IR-A3LI	CESC	TCGA	AESST	DEG_SPOP_SBC_1	0.591
p.E387K	DO44400	CESC	ICGC	AESST	DEG_SPOP_SBC_1	0.591
p.P378L	TCGA-VR-A8EX	ESCA	TCGA	AESST	DEG_SPOP_SBC_1	0.1111
p.G394E	DO233766	GACA	ICGC	AESST	DEG_SPOP_SBC_1	0.2222
p.R383Q	DO233869	GACA	ICGC	AESST	DEG_SPOP_SBC_1	0.25
p.R383L	DO228925	LICA	ICGC	AESST	DEG_SPOP_SBC_1	0.25
p.A380S	DO229038	LICA	ICGC	AESST	DEG_SPOP_SBC_1	0.1667
p.G384C	DO50906	LICA	ICGC	AESST	DEG_SPOP_SBC_1	0.2778
p.S393G	DO23360	LINC	ICGC	AESST	DEG_SPOP_SBC_1	0.25
p.S392F	DO23360	LINC	ICGC	AESST	DEG_SPOP_SBC_1	0.2778
p.Q385K	SIDM00789	Colorectal Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.3056
p.Q385K	ACH-000997	Colon/Colorectal Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.3056
p.Q385K	ACH-001061	Colon/Colorectal Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.3056
p.Q385K	HCT-15	large_intestine	COSMIC	AESST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2137:2141	AESST	SPOP	0.9956	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1244:1248	AESST	SPOP	0.7953	More...
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_SPOP_SBC_1	223:227	AESST	SPOP	0.9846	More...
Q96QE2	Proton myo-inositol cotransporter	DEG_SPOP_SBC_1	45:49	AESST	SPOP	0.5879	More...
Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	DEG_SPOP_SBC_1	60:64	AESST	SPOP	0.8136	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	540:544	AESST	SPOP	0.9672	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	386:390	AESST	SPOP	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons