DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 1244:1248

E3 ligase: SPOP

DEGRON score: 0.7953

ASA_SCORE: 83.14

COIL: 0.8826

CONS_SCORE: 0.3412

DSS_SCORE: 0.3776

HELIX: 0.0706

FCONS_SCORE: 1.1155

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1256E	TCGA-55-8208	LUAD	TCGA	AESST	DEG_SPOP_SBC_1	0.1111
p.Q1256E	DO51192	LUAD	ICGC	AESST	DEG_SPOP_SBC_1	0.1111
p.A1239V	DO225042	BRCA	ICGC	AESST	DEG_SPOP_SBC_1	0.1944
p.S1245N	SIDM00773	Non-Cancerous	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.S1245N	SIDM01126	Small Cell Lung Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.S1245N	SIDM00210	Ovarian Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.S1245N	SIDM00793	Burkitt's Lymphoma	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.S1245N	SIDM00774	Breast Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.S1245N	SIDM00720	Mesothelioma	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.S1245N	SIDM01318	Hepatocellular Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.7069
p.V1258E	SIDM00654	Small Cell Lung Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.0556
p.V1258E	NCI-H1048	lung	COSMIC	AESST	DEG_SPOP_SBC_1	0.0556
p.A1239S	ACH-000588	Myeloma	CCLE	AESST	DEG_SPOP_SBC_1	0.1944
p.T1242I	SISO	cervix	COSMIC	AESST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2137:2141	AESST	SPOP	0.9956	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1244:1248	AESST	SPOP	0.7953	More...
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_SPOP_SBC_1	223:227	AESST	SPOP	0.9846	More...
Q96QE2	Proton myo-inositol cotransporter	DEG_SPOP_SBC_1	45:49	AESST	SPOP	0.5879	More...
Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	DEG_SPOP_SBC_1	60:64	AESST	SPOP	0.8136	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	540:544	AESST	SPOP	0.9672	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	386:390	AESST	SPOP	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons