DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
AESST
Uniprot ID:
Q96QE2
Source protein:
Proton myo-inositol cotransporter
Source gene:
SLC2A13
Class:
DEG_SPOP_SBC_1
Location:
45:49
E3 ligase:
SPOP
DEGRON score:
0.5879
ASA_SCORE:
91.26
COIL:
0.719
CONS_SCORE:
0.2032
DSS_SCORE:
0.4329
HELIX:
0.2706
FCONS_SCORE:
0.9208
RIG_SCORE:
0.6738
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G58C
DO228385
LICA
ICGC
AESST
DEG_SPOP_SBC_1
0.0833
p.A35T
DO229275
THCA
ICGC
AESST
DEG_SPOP_SBC_1
0.0556
Drug responses associated with SLC2A13 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AESST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15018
PDZ domain-containing protein 2
DEG_SPOP_SBC_1
2137:2141
AESST
SPOP
0.9956
More...
P49790
Nuclear pore complex protein Nup153
DEG_SPOP_SBC_1
1244:1248
AESST
SPOP
0.7953
More...
Q8WU20
Fibroblast growth factor receptor substrate 2
DEG_SPOP_SBC_1
223:227
AESST
SPOP
0.9846
More...
Q96QE2
Proton myo-inositol cotransporter
DEG_SPOP_SBC_1
45:49
AESST
SPOP
0.5879
More...
Q9BVH7
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
DEG_SPOP_SBC_1
60:64
AESST
SPOP
0.8136
More...
Q9Y467
Sal-like protein 2
DEG_SPOP_SBC_1
540:544
AESST
SPOP
0.9672
More...
Q86X27
Ras-specific guanine nucleotide-releasing factor RalGPS2
DEG_SPOP_SBC_1
386:390
AESST
SPOP
0.9787
More...