DegronMD

Uniprot ID: Q8WU20

Source protein: Fibroblast growth factor receptor substrate 2

Source gene: FRS2

Class: DEG_SPOP_SBC_1

Location: 223:227

E3 ligase: SPOP

DEGRON score: 0.9846

ASA_SCORE: 92.52

COIL: 0.9538

CONS_SCORE: 0.3808

DSS_SCORE: 0.6844

HELIX: 0.0368

FCONS_SCORE: 1.0527

RIG_SCORE: 0.5641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P215Q	TCGA-09-2044	OV	TCGA	AESST	DEG_SPOP_SBC_1	0.1111
p.P215Q	DO28923	OV	ICGC	AESST	DEG_SPOP_SBC_1	0.1111
p.S221C	TCGA-A2-A0EQ	BRCA	TCGA	AESST	DEG_SPOP_SBC_1	0.7222
p.S221C	DO4773	BRCA	ICGC	AESST	DEG_SPOP_SBC_1	0.7222
p.A223T	TCGA-AP-A0LM	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	0.7139
p.A223T	TCGA-AP-A1DK	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	0.7139
p.A223T	DO43306	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	0.7139
p.A223T	DO42033	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	0.7139
p.S221F	TCGA-AR-A2LE	BRCA	TCGA	AESST	DEG_SPOP_SBC_1	0.7222
p.S221F	DO1932	BRCA	ICGC	AESST	DEG_SPOP_SBC_1	0.7222
p.E231Q	TCGA-B5-A0JX	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	0.2222
p.E231Q	DO43322	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	0.2222
p.E231A	TCGA-B5-A0JX	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	0.2222
p.E231A	DO43322	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	0.2222
p.R219M	TCGA-D3-A2JC	SKCM	TCGA	AESST	DEG_SPOP_SBC_1	0.2222
p.R219M	DO46777	PAEN	ICGC	AESST	DEG_SPOP_SBC_1	0.2222
p.R219M	DO47578	SKCM	ICGC	AESST	DEG_SPOP_SBC_1	0.2222
p.S233I	TCGA-DF-A2KN	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	0.1667
p.S233I	DO223282	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	0.1667
p.E217K	SIDM01588	Endometrial Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.1667
p.E217K	ACH-000993	Endometrial/Uterine Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2137:2141	AESST	SPOP	0.9956	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1244:1248	AESST	SPOP	0.7953	More...
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_SPOP_SBC_1	223:227	AESST	SPOP	0.9846	More...
Q96QE2	Proton myo-inositol cotransporter	DEG_SPOP_SBC_1	45:49	AESST	SPOP	0.5879	More...
Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	DEG_SPOP_SBC_1	60:64	AESST	SPOP	0.8136	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	540:544	AESST	SPOP	0.9672	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	386:390	AESST	SPOP	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons