DegronMD

Uniprot ID: Q9BVH7

Source protein: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

Source gene: ST6GALNAC5

Class: DEG_SPOP_SBC_1

Location: 60:64

E3 ligase: SPOP

DEGRON score: 0.8136

ASA_SCORE: 77.6

COIL: 0.7688

CONS_SCORE: 0.3024

DSS_SCORE: 0.8427

HELIX: 0.1294

FCONS_SCORE: 1.0019

RIG_SCORE: 0.5443

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S51L	TCGA-AZ-4315	COAD	TCGA	AESST	DEG_SPOP_SBC_1	0.0833
p.S51L	DO222391	BTCA	ICGC	AESST	DEG_SPOP_SBC_1	0.0833
p.S51L	DO8842	COAD	ICGC	AESST	DEG_SPOP_SBC_1	0.0833
p.P58L	TCGA-NJ-A4YP	LUAD	TCGA	AESST	DEG_SPOP_SBC_1	0.2778
p.P58L	DO218943	LUAD	ICGC	AESST	DEG_SPOP_SBC_1	0.2778
p.P74L	DO233096	GACA	ICGC	AESST	DEG_SPOP_SBC_1	0.0556
p.G54D	DO233820	GACA	ICGC	AESST	DEG_SPOP_SBC_1	0.1667
p.A50S	DO228835	LICA	ICGC	AESST	DEG_SPOP_SBC_1	0.0556
p.G73D	DO222837	MELA	ICGC	AESST	DEG_SPOP_SBC_1	0.0833
p.Q57L	DO229264	THCA	ICGC	AESST	DEG_SPOP_SBC_1	0.25
p.A72T	SIDM00678	Bladder Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.1111
p.A72T	ACH-000724	Bladder Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.1111
p.Q66K	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.2778
p.Q66K	ACH-000672	Lung Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.2778
p.A52V	SIDM01612	Endometrial Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	0.1111
p.A52V	ACH-000946	Endometrial/Uterine Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.1111
p.S56P	ACH-002200	Skin Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2137:2141	AESST	SPOP	0.9956	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1244:1248	AESST	SPOP	0.7953	More...
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_SPOP_SBC_1	223:227	AESST	SPOP	0.9846	More...
Q96QE2	Proton myo-inositol cotransporter	DEG_SPOP_SBC_1	45:49	AESST	SPOP	0.5879	More...
Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	DEG_SPOP_SBC_1	60:64	AESST	SPOP	0.8136	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	540:544	AESST	SPOP	0.9672	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	386:390	AESST	SPOP	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons