DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SPOP_SBC_1

Location: 2137:2141

E3 ligase: SPOP

DEGRON score: 0.9956

ASA_SCORE: 90.76

COIL: 0.8612

CONS_SCORE: 0.3179

DSS_SCORE: 0.5818

HELIX: 0.1222

FCONS_SCORE: 1.2146

RIG_SCORE: 0.5997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2143N	TCGA-AA-A010	COAD	TCGA	AESST	DEG_SPOP_SBC_1	0.2778
p.T2141A	TCGA-DU-7298	LGG	TCGA	AESST	DEG_SPOP_SBC_1	0.7139
p.T2141A	DO22679	LGG	ICGC	AESST	DEG_SPOP_SBC_1	0.7139
p.R2134H	DO233179	GACA	ICGC	AESST	DEG_SPOP_SBC_1	0.25
p.E2138K	DO219952	SARC	ICGC	AESST	DEG_SPOP_SBC_1	0.591
p.R2134C	ACH-001515	Cervical Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.25
p.K2127R	ACH-002659	Colon/Colorectal Cancer	CCLE	AESST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2137:2141	AESST	SPOP	0.9956	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1244:1248	AESST	SPOP	0.7953	More...
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_SPOP_SBC_1	223:227	AESST	SPOP	0.9846	More...
Q96QE2	Proton myo-inositol cotransporter	DEG_SPOP_SBC_1	45:49	AESST	SPOP	0.5879	More...
Q9BVH7	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	DEG_SPOP_SBC_1	60:64	AESST	SPOP	0.8136	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	540:544	AESST	SPOP	0.9672	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	386:390	AESST	SPOP	0.9787	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons